An establishment of novel mouse-model of intraductal tubulopapillary neoplasm of the pancreas

导管内管状乳头状肿瘤（ITPN）是一种新的胰腺癌。虽然分子异常与ITPNs癌变的关系尚不清楚，但根据我们之前的研究，PIK3CA突变可能在ITPNs的癌变中起重要作用。在本研究中，我们利用Cre-LoxP系统建立了一种新的小鼠模型，在该模型中，pik3ca突变在胰腺中被特异性诱导。目前对12 ~ 28周龄小鼠胰腺进行了详细的显微镜观察。任何胰腺肿瘤包括itpn样肿瘤未在其胰腺中观察到，但3例显示腺泡到导管化生。人itpn在形态和免疫组化水平上与胰腺小管相似。由于胰腺小管是腺泡到导管化生的主要组成部分之一，因此在我们的模型中观察到腺泡到导管化生是非常有趣的。我们的研究仍在进行中。

Intraductal tubulopapillary neoplasm (ITPN) is a new entity of pancreatic cancer. Although molecular abnormalities implicated in the oncogenesis of ITPNs are still unclear, PIK3CA mutation may play an important role in oncogenesis of ITPNs based on our previous research.In the present study, we established a novel mouse-model using Cre-LoxP system, in which PIK3CA-mutations were specifically induced in the pancreas. At present, pancreata of mice at 12 to 28 weeks were microscopically investigated in detail. Any pancreatic neoplasms including ITPN-like tumor have not been observed in their pancreata but three cases showed acinar to ductal metaplasia. ITPNs in human are similar to pancreatic ductules in morphological and immunohistochemical levels. Because pancreatic ductule is one of the main components of acinar to ductal metaplasia, it is very interesting that acinar to ductal metaplasia was observed in some cases of our model. Our study is still ongoing.