An establishment of novel mouse-model of intraductal tubulopapillary neoplasm of the pancreas
An establishment of novel mouse-model of intraductal tubulopapillary neoplasm of the pancreas
批准号:
24790358
负责人:
YAMAGUCHI Hiroshi
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
导管内管状乳头状肿瘤(ITPN)是一种新的胰腺癌。虽然分子异常与ITPNs癌变的关系尚不清楚,但根据我们之前的研究,PIK3CA突变可能在ITPNs的癌变中起重要作用。在本研究中,我们利用Cre-LoxP系统建立了一种新的小鼠模型,在该模型中,pik3ca突变在胰腺中被特异性诱导。目前对12 ~ 28周龄小鼠胰腺进行了详细的显微镜观察。任何胰腺肿瘤包括itpn样肿瘤未在其胰腺中观察到,但3例显示腺泡到导管化生。人itpn在形态和免疫组化水平上与胰腺小管相似。由于胰腺小管是腺泡到导管化生的主要组成部分之一,因此在我们的模型中观察到腺泡到导管化生是非常有趣的。我们的研究仍在进行中。
英文摘要
Intraductal tubulopapillary neoplasm (ITPN) is a new entity of pancreatic cancer. Although molecular abnormalities implicated in the oncogenesis of ITPNs are still unclear, PIK3CA mutation may play an important role in oncogenesis of ITPNs based on our previous research.In the present study, we established a novel mouse-model using Cre-LoxP system, in which PIK3CA-mutations were specifically induced in the pancreas. At present, pancreata of mice at 12 to 28 weeks were microscopically investigated in detail. Any pancreatic neoplasms including ITPN-like tumor have not been observed in their pancreata but three cases showed acinar to ductal metaplasia. ITPNs in human are similar to pancreatic ductules in morphological and immunohistochemical levels. Because pancreatic ductule is one of the main components of acinar to ductal metaplasia, it is very interesting that acinar to ductal metaplasia was observed in some cases of our model. Our study is still ongoing.
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「膵腫瘍を見直す:2010年WHO新分類を踏まえて」 Intraductal neoplasms
“重新审视胰腺肿瘤:根据 2010 年 WHO 新分类”导管内肿瘤
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[山口浩,相島慎一,小田義直, 他, 山口浩,清水道生, 山口浩,清水道生]
通讯作者:
山口浩,清水道生
膵intraductal tubulopapillary neoplasmとintraductal tubular adenomaの分子病理学的相違
胰腺导管内管状乳头状肿瘤与导管内管状腺瘤的分子病理学差异
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[山口浩,久保木友子,柴田亮行, 他]
通讯作者:
他
膵intraductal tubulopapillary neoplasmとintraductal tubular adenomaの分子病理学的相違.
胰腺导管内管状乳头状肿瘤与导管内管状腺瘤的分子病理学差异。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Hiroshi Yamaguchi, Michio Shimizu, Yuko Kuboki, et al, 山口浩,久保木友子,柴田亮行,他.]
通讯作者:
山口浩,久保木友子,柴田亮行,他.
DOI:
10.1002/path.4242
发表时间:
2013-11-01
期刊:
JOURNAL OF PATHOLOGY
影响因子:
7.3
作者:
[Yamaguchi, Hiroshi, Kuboki, Yuko, Furukawa, Toru]
通讯作者:
Furukawa, Toru
Pancreatic Hamartomas : Interesting Histopathological Findings Indicating Their "Hamartomatous" Nature
胰腺错构瘤:有趣的组织病理学发现表明其“错构瘤”性质
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Hiroshi Yamaguchi, Takuma Tajiri, Toru Furukawa, et al]
通讯作者:
et al
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