An establishment of novel mouse-model of intraductal tubulopapillary neoplasm of the pancreas

导管内乳头状肿瘤(ITPN)是一种新的胰腺癌实体。尽管ITPNS致癌的分子机制尚不清楚，但在我们前期研究的基础上，PIK3CA突变可能在ITPNS的致癌过程中起重要作用。在本研究中，我们利用Cre-loxP系统建立了一种新的小鼠模型，其中PIK3CA突变是在胰腺中特异性诱导的。目前，对12~28周龄小鼠的胰腺进行了详细的显微镜观察。未发现胰腺肿瘤，包括ITPN样瘤，但3例腺泡至导管化生。人的ITPN在形态和免疫组织化学水平上与胰管相似。由于胰管是腺泡-导管化生的主要成分之一，在我们的模型中观察到腺泡-导管化生是非常有趣的。我们的研究仍在进行中。

Intraductal tubulopapillary neoplasm (ITPN) is a new entity of pancreatic cancer. Although molecular abnormalities implicated in the oncogenesis of ITPNs are still unclear, PIK3CA mutation may play an important role in oncogenesis of ITPNs based on our previous research.In the present study, we established a novel mouse-model using Cre-LoxP system, in which PIK3CA-mutations were specifically induced in the pancreas. At present, pancreata of mice at 12 to 28 weeks were microscopically investigated in detail. Any pancreatic neoplasms including ITPN-like tumor have not been observed in their pancreata but three cases showed acinar to ductal metaplasia. ITPNs in human are similar to pancreatic ductules in morphological and immunohistochemical levels. Because pancreatic ductule is one of the main components of acinar to ductal metaplasia, it is very interesting that acinar to ductal metaplasia was observed in some cases of our model. Our study is still ongoing.