analysis of the mechanism of bone and articular destruction in dialysis related amyloidosis

为揭示透析相关性淀粉样变性中β2微球蛋白(β2 m)淀粉样纤维沉积导致骨和关节破坏的机制，我们研究了β2 m淀粉样纤维对兔滑膜成纤维细胞的细胞毒性作用。在培养液中加入β2-m淀粉样蛋白纤维后，兔滑膜成纤维细胞出现坏死和凋亡。提示β2-m淀粉样蛋白纤维对滑膜细胞的直接细胞毒性作用可能与β2-m淀粉样蛋白沉积导致的骨和关节破坏有关。

To reveal the way that deposition of β2-microglobulin (β2-m) amyloid fibrils in dialysis related amyloidosis induce bone and articular destruction, we investigated the cytotoxicity of β2-m amyloid fibrils to rabbit synovial fibroblasts. Necrosis and apoptosis of rabbit synovial fibroblasts were induced when β2-m amyloid fibrils were added to the culture medium. This result suggests that direct cytotoxicity of β2-m amyloid fibrils to synovial cells may involve the pathogenesis in bone a nd articular destruction by deposition of β2-m amyloid.