Analysis of gastric and intestinal phenotype of gastric cancer in asymmetrical cell division
Analysis of gastric and intestinal phenotype of gastric cancer in asymmetrical cell division
批准号:
23790401
负责人:
OUE Naohide
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
在本研究中,我们分析了肿瘤干细胞标记物和胃癌胃肠表型的转变。基因芯片分析表明,转录因子KLF-2和Ets-2在侧群细胞中高表达。我们还发现整合素a2异构体在侧群细胞中表达。KLF-5和Ets-2基因被敲除后,侧群细胞比例减少。整合素a2在呈垂直分裂的细胞中表达。这些分子是癌症干细胞的潜在标记。
英文摘要
In the present study, we analyzed cancer stem cell marker and transition of gastric or intestinal phenotype in gastric cancer. GeneChip analysis revealed that KLF-2 and Ets-2, which are transcriptional factor, were over-expressed in side-population cells. We also found that integrin a2 isover-expressed in side-population cells. Fraction of side-population cell was reduced by knockdown of KLF-5 and Ets-2. Integrin a2 was expressed in cells showing perpendicular division. These molecules are potential marker for cancer stem cells.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1371/journal.pone.0047545
发表时间:
2012
期刊:
PloS one
影响因子:
3.7
作者:
[Naito Y, Oue N, Hinoi T, Sakamoto N, Sentani K, Ohdan H, Yanagihara K, Sasaki H, Yasui W]
通讯作者:
Yasui W
SAGE 法、CAST 法から明らかになった胃型・腸型胃癌の生物学的・臨床的特徴
SAGE和CAST方法揭示胃型和肠型胃癌的生物学和临床特征
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kuroda A, Tsukamoto Y, Nguyen LT,Noguchi T, Takeuchi I, Uchida M, Uchida T, Hijiya N, Nakada C, Okimoto T, Kodama M, Murakami K, Matsuura K, Seto M, Ito H, Fujioka T, Moriyama M, 大上直秀]
通讯作者:
大上直秀
消化器癌発生・進展と微小環境:SEC11Aの胃癌における高発現とTGF-α/EGF分泌促進作用
胃肠道癌发生、发展及微环境:胃癌中SEC11A高表达及TGF-α/EGF分泌促进作用
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Takeshi Matsuzawa, Bae-Hoon Kim, Avinash R. Shenoy, Shhigeki Kamittani, Masami Miyaake, and Johhn D. MacMicking、, 大上直秀]
通讯作者:
大上直秀
DOI:
10.1159/000341396
发表时间:
2012-08
期刊:
Pathobiology
影响因子:
5
作者:
[Tetsutaro Hayashi;K. Sentani;N. Oue;S. Ohara;J. Teishima;Katsuhiro Anami;N. Sakamoto;A. Matsubara;W. Yasui]
通讯作者:
Tetsutaro Hayashi;K. Sentani;N. Oue;S. Ohara;J. Teishima;Katsuhiro Anami;N. Sakamoto;A. Matsubara;W. Yasui
Infantile adenomyoma subclinically excreted into the patient's diaper.
婴儿腺肌瘤在亚临床状态下排泄到患者的尿布中。
DOI:
10.1111/j.1440-1827.2012.02829.x
发表时间:
2012
期刊:
Pathol Int
影响因子:
2.2
作者:
[Anami K, Sentani K, Sakamoto N, Uraoka N, Oue N, Yasui W.]
通讯作者:
Yasui W.
共 35 条
CAST analysis of gastric cancer with gastric and intestinal phenotype
-
批准号:21790354
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2009
-
负责人:OUE Naohide
-
依托单位:
Gene expression profile of gastric cancer with gastric and intestinal phenotype
-
批准号:19790261
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.36万
-
财政年份:2007
-
负责人:OUE Naohide
-
依托单位:
海外基金