Analysis of gastric and intestinal phenotype of gastric cancer in asymmetrical cell division

胃癌胃、肠细胞不对称分裂表型分析

• 批准号: 23790401
• 负责人: OUE Naohide
• 金额: $ 2.75万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790401/
• 关键词: 分子病理; 腫瘍; 胃癌; 形質発現; 癌; 病理学; がん

In the present study, we analyzed cancer stem cell marker and transition of gastric or intestinal phenotype in gastric cancer. GeneChip analysis revealed that KLF-2 and Ets-2, which are transcriptional factor, were over-expressed in side-population cells. We also found that integrin a2 isover-expressed in side-population cells. Fraction of side-population cell was reduced by knockdown of KLF-5 and Ets-2. Integrin a2 was expressed in cells showing perpendicular division. These molecules are potential marker for cancer stem cells.

在本研究中，我们分析了胃癌干细胞标志物和胃或肠表型的转变。基因芯片分析显示，转录因子KLF-2和Ets-2在侧群细胞中过表达。我们还发现整合素α 2在侧群细胞中过表达。侧群细胞的分数通过KLF-5和Ets-2的敲低而减少。整合素α 2在显示垂直分裂的细胞中表达。这些分子是癌症干细胞的潜在标志物。

项目成果

Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer.

• DOI: 10.1371/journal.pone.0047545
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Naito Y;Oue N;Hinoi T;Sakamoto N;Sentani K;Ohdan H;Yanagihara K;Sasaki H;Yasui W
• 通讯作者: Yasui W

SAGE 法、CAST 法から明らかになった胃型・腸型胃癌の生物学的・臨床的特徴

SAGE和CAST方法揭示胃型和肠型胃癌的生物学和临床特征

• 发表时间: 2012
• 作者: Kuroda A;Tsukamoto Y;Nguyen LT,Noguchi T;Takeuchi I;Uchida M; Uchida T;Hijiya N;Nakada C;Okimoto T;Kodama M;Murakami K; Matsuura K;Seto M;Ito H;Fujioka T;Moriyama M;大上直秀
• 通讯作者: 大上直秀

消化器癌発生・進展と微小環境:SEC11Aの胃癌における高発現とTGF-α/EGF分泌促進作用

胃肠道癌发生、发展及微环境：胃癌中SEC11A高表达及TGF-α/EGF分泌促进作用

• 发表时间: 2011
• 作者: Takeshi Matsuzawa;Bae-Hoon Kim;Avinash R. Shenoy;Shhigeki Kamittani;Masami Miyaake;and Johhn D. MacMicking、;大上直秀
• 通讯作者: 大上直秀

The Search for Secreted Proteins in Prostate Cancer by the Escherichia coli Ampicillin Secretion Trap: Expression of NBL1 Is Highly Restricted to the Prostate and Is Related to Cancer Progression

• DOI: 10.1159/000341396
• 发表时间: 2012-08
• 期刊: Pathobiology
• 影响因子: 5
• 作者: Tetsutaro Hayashi;K. Sentani;N. Oue;S. Ohara;J. Teishima;Katsuhiro Anami;N. Sakamoto;A. Matsubara;W. Yasui

Infantile adenomyoma subclinically excreted into the patient's diaper.

婴儿腺肌瘤在亚临床状态下排泄到患者的尿布中。

• DOI: 10.1111/j.1440-1827.2012.02829.x
• 发表时间: 2012
• 期刊: Pathol Int
• 影响因子: 2.2
• 作者: Anami K;Sentani K;Sakamoto N;Uraoka N;Oue N;Yasui W.
• 通讯作者: Yasui W.