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Genomic Profiling of Submucosal-Invasive Gastric Cancer by Array-Based Comparative Genomic Hybridization

通过基于阵列的比较基因组杂交对粘膜下浸润性胃癌进行基因组分析

基本信息

批准号：
23790409
负责人：
KURODA Akiko
金额：
$ 2.66万
依托单位：
Oita University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2012
项目状态：
已结题

项目摘要

Last year, we reported that gain of 11q, 14q and amplification of 17q21 were more frequent in metastatic submucosal-invasive gastric cancers (SMGC). This year, we compared their genomic profiles between paired samples of mucosal (MU) andsubmucosal (SM) invasion. Eleven of the 23 cases showed an increased number ofCNAs in the SM portion as compared with the MU portion, 11 showed a decreased number,identifying that accumulation of chromosomal aberrations were not necessary withsubmucosal invasion. This result suggested that limited tumor cells among many subpopulations couldinvade into the submucosa and form subpopulations genetically distinct from the invasive one. On the basis of these findings, we proposed the clonal evolution model for the process of SM invasion of early gastric cancer.

去年，我们报道了11q、14q的增加和17q21的扩增在转移性粘膜下浸润性胃癌（SMGC）中更为常见。今年，我们比较了它们在粘膜（MU）和粘膜下（SM）侵袭的配对样本之间的基因组图谱。23例中有11例显示SM部分的cnas数量比MU部分增加，11例显示cnas数量减少，这表明染色体畸变的积累与粘膜下浸润并不是必需的。这一结果表明，在许多亚群中，有限的肿瘤细胞可以侵入粘膜下层，并形成与侵入性不同的亚群。在此基础上，我们提出了SM侵袭早期胃癌过程的克隆进化模型。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Genomic profiling of submucosal-invasive gastric cancer by array-based comparative genomic hybridization.

DOI：
10.1371/journal.pone.0022313
发表时间：
2011
期刊：
PloS one
影响因子：
3.7
作者：
Kuroda A;Tsukamoto Y;Nguyen LT;Noguchi T;Takeuchi I;Uchida M;Uchida T;Hijiya N;Nakada C;Okimoto T;Kodama M;Murakami K;Matsuura K;Seto M;Ito H;Fujioka T;Moriyama M
通讯作者：
Moriyama M

A Diagnosis of Depression Should Be Considered in Patients with Multiple Physical Symptoms in Primary Care Clinics

初级保健诊所出现多种身体症状的患者应考虑抑郁症的诊断