Genomic Profiling of Submucosal-Invasive Gastric Cancer by Array-Based Comparative Genomic Hybridization

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Last year, we reported that gain of 11q, 14q and amplification of 17q21 were more frequent in metastatic submucosal-invasive gastric cancers (SMGC). This year, we compared their genomic profiles between paired samples of mucosal (MU) andsubmucosal (SM) invasion. Eleven of the 23 cases showed an increased number ofCNAs in the SM portion as compared with the MU portion, 11 showed a decreased number,identifying that accumulation of chromosomal aberrations were not necessary withsubmucosal invasion. This result suggested that limited tumor cells among many subpopulations couldinvade into the submucosa and form subpopulations genetically distinct from the invasive one. On the basis of these findings, we proposed the clonal evolution model for the process of SM invasion of early gastric cancer.