Analysis of novel pathway for inflammatory responses induced by Mycoplasma pneumonia
肺炎支原体诱导炎症反应新途径分析
基本信息
- 批准号:23790488
- 负责人:
- 金额:$ 2.83万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Young Scientists (B)
- 财政年份:2011
- 资助国家:日本
- 起止时间:2011 至 2013
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Mycoplasma pneumoniae induced pneumonia in human. Lipoproteins of M. pneumoniae and its receptor Toll-like Receptor (TLR) 2 were have been thought to be important to induce inflammation. However, in this study, we demonstrated that M. pneumoniae induced inflammatory responses through TLR2-independent pathway. TLR4 and autophagy played important roles in the induction of TLR2-independent pathway. Moreover, transposon mutagenesis revealed that cytadherence of M. pneumoniae was important factor for the induction. Overall, these results suggest that cytadherence of M. pneumoniae induces inflammatory responses through TLR4 and autophagy.
肺炎支原体诱发人类肺炎。M.肺炎克雷伯氏菌及其受体Toll样受体(TLR)2被认为是诱导炎症的重要因素。然而,在这项研究中,我们证明了M。pneumoniae通过TLR2非依赖性途径诱导炎症反应。TLR4和自噬在TLR2非依赖性通路的诱导中起重要作用。转座子诱变结果表明,M. pneumoniae是诱导的重要因素。总之,这些结果表明,M.肺炎链球菌通过TLR4和自噬诱导炎症反应。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Novel Bacterial Lipoprotein Structures Conserved in Low-GC Content Gram-positive Bacteria Are Recognized by Toll-like Receptor 2
- DOI:10.1074/jbc.m111.292235
- 发表时间:2012-04-13
- 期刊:
- 影响因子:4.8
- 作者:Kurokawa, Kenji;Ryu, Kyoung-Hwa;Lee, Bok Luel
- 通讯作者:Lee, Bok Luel
Mycoplasma pneumoniaeの細胞接着によるTLR4を介した炎症誘導
TLR4介导的肺炎支原体细胞粘附诱导炎症
- DOI:
- 发表时间:2014
- 期刊:
- 影响因子:0
- 作者:清水隆;橘理人;度会雅久
- 通讯作者:度会雅久
Unique Pathway of Inflammatory Responses induced by Mycoplasma pneumoniae
肺炎支原体引起炎症反应的独特途径
- DOI:
- 发表时间:2013
- 期刊:
- 影响因子:0
- 作者:清水隆;桑野剛一;木田豊;橘理人;度会雅久
- 通讯作者:度会雅久
Cytadherence of Mycoplasma pneumoniae Induces Inflammatory Responses through Autophagy and Toll-Like Receptor 4
- DOI:10.1128/iai.01961-14
- 发表时间:2014-07-01
- 期刊:
- 影响因子:3.1
- 作者:Shimizu, Takashi;Kimura, Yui;Watarai, Masahisa
- 通讯作者:Watarai, Masahisa
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SHIMIZU Takashi其他文献
Corporate stability and corporate systems(in Japanese)
企业稳定性和企业制度(日语)
- DOI:
- 发表时间:
2004 - 期刊:
- 影响因子:0
- 作者:
SHIMIZU Takashi - 通讯作者:
SHIMIZU Takashi
Kigyou ni taisuru seisai mechanism: keiji hou to minji hou no hikaku no kokoromi
Kigyou ni taisuru seisai机制:keiji hou to minji hou no hikaku no kokoromi
- DOI:
- 发表时间:
2003 - 期刊:
- 影响因子:0
- 作者:
SHIMIZU Takashi;HATANAKA Kaori;MURAMATSU Kanji - 通讯作者:
MURAMATSU Kanji
Dokusen kinshi hou ihan ni taisuru seisaino keieikouka
独行近视后伊汉尼泰苏鲁 Seisaino keieikouka
- DOI:
- 发表时间:
2003 - 期刊:
- 影响因子:0
- 作者:
清水剛;畠中薫里;村松幹二;井庭崇;井庭崇;井庭崇;山本和也;原田至郎;山影進;SHIMIZU Takashi - 通讯作者:
SHIMIZU Takashi
Shortening of corporate life and impact in 1990's(in Japanese)
20世纪90年代企业寿命的缩短及其影响(日语)
- DOI:
- 发表时间:
2006 - 期刊:
- 影响因子:0
- 作者:
大塚時雄;三友仁志;SHIMIZU Takashi - 通讯作者:
SHIMIZU Takashi
SHIMIZU Takashi的其他文献
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{{ truncateString('SHIMIZU Takashi', 18)}}的其他基金
To Create a Database on Conferences Report of "Religion Division" CIE GHQ/SCAP and Construct a Website for effective use
创建“宗教部”CIE GHQ/SCAP会议报告数据库并构建有效使用的网站
- 批准号:
15K02843 - 财政年份:2015
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Functions of legal business forms and development of economy and society - A comparaive study of Asian countries
合法商业形态的功能与经济社会发展——亚洲国家比较研究
- 批准号:
26380455 - 财政年份:2014
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The autonomy of organizations and the control by shareholders: A comparative analysis of the interactions between legal forms of business and organizations
组织的自治与股东的控制:企业法律形式与组织之间相互作用的比较分析
- 批准号:
23730343 - 财政年份:2011
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Analysis of Money and Communication as Equilibrium Phenomenon
货币与传播作为均衡现象的分析
- 批准号:
23530233 - 财政年份:2011
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Ovarian follicular cell dysfunction by lipopolysaccharide
脂多糖导致卵巢滤泡细胞功能障碍
- 批准号:
23580383 - 财政年份:2011
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The molecular analysis of the development of cerebellum by using zebrafish mutants
利用斑马鱼突变体对小脑发育进行分子分析
- 批准号:
22570201 - 财政年份:2010
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The development of guidline for cost accounting that fits in modern production systems.
制定适合现代生产系统的成本核算指南。
- 批准号:
22330138 - 财政年份:2010
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Research on the component technology for the realization of ultralow-loss millimeter-wave filters
超低损耗毫米波滤波器实现的器件技术研究
- 批准号:
21760248 - 财政年份:2009
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Investigation of new historical materials concerning GHQ/SCAP's religious policy
有关 GHQ/SCAP 宗教政策的新历史材料的调查
- 批准号:
21720242 - 财政年份:2009
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Functional analysis of Toll-like receptor 10
Toll样受体10的功能分析
- 批准号:
20790342 - 财政年份:2008
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Young Scientists (B)














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