Functional analysis of Toll-like receptor 10
Functional analysis of Toll-like receptor 10
批准号:
20790342
负责人:
SHIMIZU Takashi
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
293 T细胞中TLR 10的表达通过TLR 2抑制脂蛋白对NF-κB的激活。本实验研究了TLR 10和TLR 2非依赖性肺炎支原体细胞粘附诱导的炎症反应之间的关系。通过M.肺炎依赖于ATP和P2 X7受体,而不依赖于TLR 10。
英文摘要
TLR10 expression in 293T cells suppressed the activation of NF-κB by lipoproteins through TLR2. This result indicates that TLR10 plays an important role to inhibit and control the inflammatory responses induced by TLR2.We examined the relationship between TLR10 and TLR2 independent inflammatory responses induced by cytoadherence of Mycoplasma pneumoniae. The induction of TLR2 independent inflammatory responses by cytoadherence of M. pneumonia was dependent of ATP and P2X7 receptor, but independent of TLR10.
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炎症を誘導する病原性マイコプラズマのリポプロテイン
诱发炎症的致病性支原体脂蛋白
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[清水隆, 木田豊, 桑野剛一]
通讯作者:
桑野剛一
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Shimizu T, Kida Y, Kuwano K]
通讯作者:
Kuwano K
Mycoplasma genitalium由来リポタンパク質によるToll-like receptorシグナルの活性化
生殖支原体衍生脂蛋白激活 Toll 样受体信号
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[清水隆, 木田豊, 桑野剛一]
通讯作者:
桑野剛一
Helicobacter pyliriの炎症誘導リポプロテインの同定
幽门螺杆菌中炎症诱导脂蛋白的鉴定
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[清水隆, 三室仁美]
通讯作者:
三室仁美
Cytoadherence-dependent Induction of Inflammatory Responses by ycoplasma pneumoniae
肺炎支原体对细胞粘附依赖性炎症反应的诱导
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Shimizu T, Kida Y, Kuwano K, 清水隆]
通讯作者:
清水隆
共 11 条
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Ovarian follicular cell dysfunction by lipopolysaccharide
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Analysis of novel pathway for inflammatory responses induced by Mycoplasma pneumonia
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The molecular analysis of the development of cerebellum by using zebrafish mutants
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The development of guidline for cost accounting that fits in modern production systems.
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Research on the component technology for the realization of ultralow-loss millimeter-wave filters
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Investigation of new historical materials concerning GHQ/SCAP's religious policy
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The molecular analysis of the formation of anterior -posterior axis by Cdx-Hox code
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A GAME-THEORETIC ANALYSIS OF MARKET MECHANISM IN DYNAMIC ENVIRONMENT
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The role of Wnt signals in the formation of posterior tissue in zebrafish
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The molecular analysis of the dorsal organizer formation in zebrafish early development.
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Mesodermal determinants in the Tubifex embryo
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The analysis of dharma/bozozok gene function in vertebrates body axis formation.
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Strategic planning and performance evaluation on global com
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Lineage-specific segregation of maternal mRNA
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Analysis of Factors Generating Inequality in Early Cleavages in Tubifex
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海外基金