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Functional analysis of Toll-like receptor 10

Functional analysis of Toll-like receptor 10
Toll样受体10的功能分析
批准号:
20790342
负责人:
SHIMIZU Takashi
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
翻译
293T细胞中TLR10的表达通过TLR2抑制脂蛋白对NF-κB的激活。这一结果表明TLR10在抑制和控制TLR2诱导的炎症反应中起着重要作用。我们研究了肺炎支原体细胞粘附诱导的TLR10和TLR2非依赖性炎症反应之间的关系。肺炎支原体细胞粘附诱导TLR2非依赖性炎症反应依赖于ATP和P2X7受体,但不依赖于TLR10。
英文摘要
TLR10 expression in 293T cells suppressed the activation of NF-κB by lipoproteins through TLR2. This result indicates that TLR10 plays an important role to inhibit and control the inflammatory responses induced by TLR2.We examined the relationship between TLR10 and TLR2 independent inflammatory responses induced by cytoadherence of Mycoplasma pneumoniae. The induction of TLR2 independent inflammatory responses by cytoadherence of M. pneumonia was dependent of ATP and P2X7 receptor, but independent of TLR10.
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DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [清水隆, 木田豊, 桑野剛一]
通讯作者: 桑野剛一
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Shimizu T, Kida Y, Kuwano K]
通讯作者: Kuwano K
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [清水隆, 木田豊, 桑野剛一]
通讯作者: 桑野剛一
Helicobacter pyliriの炎症誘導リポプロテインの同定
幽门螺杆菌中炎症诱导脂蛋白的鉴定
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [清水隆, 三室仁美]
通讯作者: 三室仁美
共 11 条
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    • 批准号:
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    • 项目类别:
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    • 财政年份:
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    • 依托单位:
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    • 资助金额:
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    • 批准号:
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    • 资助金额:
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    • 财政年份:
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    • 项目类别:
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    • 财政年份:
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    • 负责人:
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