Study on the interaction between M cells and immune cells in Peyer' spatch.

派尔氏淋巴集结M细胞与免疫细胞相互作用的研究

• 批准号: 23790521
• 负责人: KIMURA Shunsuke
• 金额: $ 2.83万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790521/
• 关键词: パイエル板; M細胞; 粘膜免疫; 細胞間相互作用

Peyer's patch (PP) in the small intestine is a primary site for the intestinal immune system. The luminal side of PPs is covered by the follicle-associated epithelium (FAE), which contains M cells, which uptake antigens or macromolecules, and deliver them to dendritic cells inhabiting subepithelial dome region under FAE. CCR1 is a receptor of Ccl9 which is belonging to the CC chemokine family and highly expressed in M cells. We found that CCR1 positive cells inhabit subepithelial dome region, and some of them contact with M cells. Moreover, our study suggests that CCR1 positive cell belongs to a subtype of antigen-producing plasma cells.

小肠中的Peyer斑块（PP）是肠道免疫系统的主要部位。 PPS的腔侧被卵泡相关上皮（FAE）覆盖，其中包含M细胞，其中摄取抗原或大分子，并将其输送到居住在FAE下的上皮下圆顶区域的树突状细胞。 CCR1是CCL9的受体，属于CC趋化因子家族，在M细胞中高度表达。我们发现CCR1阳性细胞居住在上皮下圆顶区域，其中一些细胞与M细胞接触。此外，我们的研究表明，CCR1阳性细胞属于产生抗原的浆细胞的亚型。

项目成果

The role of M-Sec in tunneling nanotube formation

M-Sec 在隧道纳米管形成中的作用

• 发表时间: 2011
• 作者: Ohno;H
• 通讯作者: H

M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex

• DOI: 10.1038/ncb1990
• 发表时间: 2009-12-01
• 期刊: NATURE CELL BIOLOGY
• 影响因子: 21.3
• 作者: Hase, Koji;Kimura, Shunsuke;Ohno, Hiroshi
• 通讯作者: Ohno, Hiroshi

The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice.

• DOI: 10.1053/j.gastro.2011.04.056
• 发表时间: 2011-08
• 期刊: Gastroenterology
• 影响因子: 29.4
• 作者: D. Takahashi;K. Hase;S. Kimura;F. Nakatsu;M. Ohmae;Y. Mandai;Toru Sato;Y. Date;M. Ebisawa;Tamotsu Kato;Yuuki Obata;S. Fukuda;Y. Kawamura;T. Dohi;T. Katsuno;O. Yokosuka;S. Waguri;H. Ohno