Analysis of the mechanism for the regulation of antibody responses by inflammation-associated remodeling of lymph nodes

在这项研究中，我试图阐明淋巴(LN)重塑调节抗体反应的机制。通过这项研究，我获得了以下认识：1)LN间质网络的分子组成与LN T细胞区的分子组成非常相似；2)抗原非特异性B细胞介导的LN髓质重塑调节抗原特异性抗体反应；3)纤维母细胞网状细胞(FRC)激活后，作为LN间质网络的主要细胞类型，在不增加数量的情况下经历周转；4)激活的FRC促进抗原特异性辅助T细胞反应的收缩，从而影响滤泡辅助T细胞的数量。

In this study, I sought to clarify the mechanism for the regulation of antibody responses by lymph node (LN) remodeling. I obtained the following insights through this study: 1) Molecular components of stromal network in LN medulla resembled closely to those in T cell region of the LN; 2) Medullary remodeling of LN mediated by antigen-non-specific B cells regulate the antigen-specific antibody response; 3) Upon activation, fibroblastic reticular cells (FRCs), the major cell type shaping the LN stromal network, undergo the turnover without expansion of their number; 4) Activated FRCs promote the contraction of antigen-specific helper T cell response, thereby affecting the number of follicular helper T cells.