Analysis of the mechanism for the regulation of antibody responses by inflammation-associated remodeling of lymph nodes

炎症相关淋巴结重塑调节抗体反应的机制分析

• 批准号: 23790525
• 负责人: ABE Jun
• 金额: $ 2.75万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790525/
• 关键词: 獲得免疫; リンパ節; 間質細胞ネットワーク; CD4陽性ヘルパーT細胞; ゲノムワイド遺伝子発現解析; 間質ネットワーク; リモデリング; 抗体産生

In this study, I sought to clarify the mechanism for the regulation of antibody responses by lymph node (LN) remodeling. I obtained the following insights through this study: 1) Molecular components of stromal network in LN medulla resembled closely to those in T cell region of the LN; 2) Medullary remodeling of LN mediated by antigen-non-specific B cells regulate the antigen-specific antibody response; 3) Upon activation, fibroblastic reticular cells (FRCs), the major cell type shaping the LN stromal network, undergo the turnover without expansion of their number; 4) Activated FRCs promote the contraction of antigen-specific helper T cell response, thereby affecting the number of follicular helper T cells.

在这项研究中，我试图澄清淋巴结（LN）重塑调节抗体反应的机制。通过本研究，我获得了以下认识：1）LN髓质基质网络的分子组成与LN T细胞区的分子组成相似：2）抗原非特异性B细胞介导的LN髓质重塑调节抗原特异性抗体反应; 3）活化后，成纤维网状细胞（FRC），形成LN基质网络的主要细胞类型，4）活化的FRC促进抗原特异性辅助性T细胞应答的收缩，从而影响滤泡辅助性T细胞的数量。

项目成果

Cognate and non-cognate B cells mediate the remodeling of lymph node medulla that contributes to antibody responses

同源和非同源 B 细胞介导淋巴结髓质重塑，从而促进抗体反应

• 发表时间: 2011
• 作者: Jun Abe;Satoshi Ueha;Yusuke Shono;Makoto Kurachi;Michio Tomura;Kazuhiro Kakimi;and Kouji Matsushima
• 通讯作者: and Kouji Matsushima

Coordinated Changes in DNA Methylation in Antigen-Specific Memory CD4 T Cells

• DOI: 10.4049/jimmunol.1202267
• 发表时间: 2013-04-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Hashimoto, Shin-ichi;Ogoshi, Katsumi;Matsushima, Kouji
• 通讯作者: Matsushima, Kouji

B cells regulate antibody responses through the medullary remodeling of inflamed lymph nodes

• DOI: 10.1093/intimm/dxr089
• 发表时间: 2012-01-01
• 期刊: INTERNATIONAL IMMUNOLOGY
• 影响因子: 4.4
• 作者: Abe, Jun;Ueha, Satoshi;Matsushima, Kouji
• 通讯作者: Matsushima, Kouji

Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration.

趋化因子受体CXCR3促进CD8（+）T细胞分化为短寿命的效应细胞，导致记忆变性。

• DOI: 10.1084/jem.20102101
• 发表时间: 2011-08-01
• 期刊: The Journal of experimental medicine
• 作者: Kurachi M;Kurachi J;Suenaga F;Tsukui T;Abe J;Ueha S;Tomura M;Sugihara K;Takamura S;Kakimi K;Matsushima K
• 通讯作者: Matsushima K

B cells regulate antibody responses through the medullary remodeling of antigen-draining lymph nodes

B 细胞通过抗原引流淋巴结的髓质重塑来调节抗体反应

• 发表时间: 2013
• 作者: Moi ML;Lim CK;Saijo M;Takasaki T;Kurane I;Abe J
• 通讯作者: Abe J