AhR regulates innate immune responses and Th17 cell differentiation

AhR 调节先天免疫反应和 Th17 细胞分化

• 批准号: 23790545
• 负责人: KIMURA Akihiro
• 金额: $ 2.75万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790545/
• 关键词: ダイオキシン受容体; listeria monocytogenes; 活性酸素; マクロファージ; AIM; リステリア; リステリオリジン O

AhR plays an important role in the host defense against Listeria monocytogenes(LM) infection. While AhR suppresses LM-induced pro-inflammatory cytokine production, AhR inhibits the cell death of macrophages infectedwith LM. In addition, AhR participates i

AhR在宿主防御单核细胞增生李斯特菌（Listeria monocytogenes，LM）感染中起重要作用。虽然AhR抑制LM诱导的促炎细胞因子的产生，但AhR抑制LM感染的巨噬细胞的细胞死亡。此外，AhR还参加了

项目成果

Forced expression of stabilized c-Fos in dendritic cells reduces cytokine production and immune responses in vivo.

• DOI: 10.1016/j.bbrc.2012.05.097
• 发表时间: 2012-06
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Ryoko Yoshida;Mayu Suzuki;Ryota Sakaguchi;Eiichi Hasegawa;A. Kimura;T. Shichita;T. Sekiya;H. Shiraishi;K. Shimoda;A. Yoshimura

SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production.

• DOI: 10.1084/jem.20110428
• 发表时间: 2011-09-26
• 期刊: The Journal of experimental medicine
• 作者: Takahashi R;Nishimoto S;Muto G;Sekiya T;Tamiya T;Kimura A;Morita R;Asakawa M;Chinen T;Yoshimura A
• 通讯作者: Yoshimura A

Aryl hydrocarbon receptor/IDO産生樹状細胞によるレギュラトリーT細胞の誘導. 臨床免疫・アレルギー科、57

产生芳基烃受体/IDO 的树突状细胞诱导调节性 T 细胞，临床免疫学和过敏系，57。

• 发表时间: 2012
• 作者: 木村彰宏

SOCS1 regulates type I/type II NKT cell balance by regulating IFNgamma signaling.

SOCS1 通过调节 IFNgamma 信号传导来调节 I 型/II 型 NKT 细胞平衡。

• 发表时间: 2011
• 期刊: Int Immunol 23
• 作者: Hashimoto M;Hiwatashi K;Ichiyama K;Morita R;Sekiya T;Kimura A;Sugiyama Y;Sibata T;Kuroda K;Takahashi R;Yoshimura A.
• 通讯作者: Yoshimura A.

Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation

• DOI: 10.1016/j.bbrc.2011.12.156
• 发表时间: 2012-02-10
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Yoshida, Hideyuki;Kimura, Akihiro;Yoshimura, Akihiko
• 通讯作者: Yoshimura, Akihiko