Aryl hydrocarbon receptor regulates innate and acquired immune resposes

芳基烃受体调节先天和获得性免疫反应

• 批准号: 21790468
• 负责人: KIMURA Akihiro
• 金额: $ 2.75万
• 依托单位: Keio University (2010)Osaka University (2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790468/
• 关键词: Ahr; LPS; マクロファージ; 関節リウマチ; 自然免疫; ダイオキシン受容体; リステリア; IL-6

Ahr is induced in macrophages stimulated by LPS. The production of IL-6 and tumor necrosis factor (TNF)-α by LPS was significantly elevated in Ahr-deficient macrophages compared to that in wild-type (WT) cells. Ahr forms a complex with Stat1 and nuclear factor-kappa B (NF-κB) in macrophages stimulated by LPS, which leads to inhibition of the promoter activity of IL-6. Ahr thus plays an essential role in the negative regulation of the LPS signaling pathway through interaction with Stat1. In dendritic cells, Ahr induces the expression of IDO, which promotes Treg cell differentiation.

在LPS刺激的巨噬细胞中诱导Ahr。与野生型（WT）细胞相比，Ahr缺陷型巨噬细胞中LPS产生的IL-6和肿瘤坏死因子（TNF）-α显著升高。Ahr在LPS刺激的巨噬细胞中与Stat 1和核因子-κ B（NF-κB）形成复合物，导致IL-6启动子活性的抑制。因此，Ahr通过与Stat 1相互作用在LPS信号通路的负调控中起着重要作用。在树突状细胞中，Ahr诱导IDO的表达，IDO促进Treg细胞分化。

项目成果

The Influence of Excessive IL-6 Production In Vivo on the Development and Function of Foxp3+ Regulatory T Cells

• DOI: 10.4049/jimmunol.0903314
• 发表时间: 2011-01-01
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Fujimoto, Minoru;Nakano, Mayumi;Naka, Tetsuji
• 通讯作者: Naka, Tetsuji

感染 炎症 免疫

感染炎症免疫

• 发表时间: 2019
• 作者: 植木紘史;河岡義裕
• 通讯作者: 河岡義裕

Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses.

• DOI: 10.1084/jem.20090560
• 发表时间: 2009-08-31
• 期刊: The Journal of experimental medicine
• 作者: Kimura A;Naka T;Nakahama T;Chinen I;Masuda K;Nohara K;Fujii-Kuriyama Y;Kishimoto T
• 通讯作者: Kishimoto T

SOCS1 regulates type I/type II NKT cell balance by regulating IFNgamma signaling.

SOCS1 通过调节 IFNgamma 信号传导来调节 I 型/II 型 NKT 细胞平衡。

• 发表时间: 2011
• 期刊: Int Immunol 23
• 作者: Hashimoto M;Hiwatashi K;Ichiyama K;Morita R;Sekiya T;Kimura A;Sugiyama Y;Sibata T;Kuroda K;Takahashi R;Yoshimura A.
• 通讯作者: Yoshimura A.

Th17細胞の分化とaryl hydrocarbon receptor(臨床免疫・アレルギー科52)

Th17 细胞分化和芳烃受体（临床免疫学和过敏 52）

• 发表时间: 2009
• 作者: 木村彰宏;岸本忠三
• 通讯作者: 岸本忠三