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Study on the health effects of industrial chemical with potential hepatotoxicity

Study on the health effects of industrial chemical with potential hepatotoxicity
具有潜在肝毒性的工业化学品对健康的影响研究
批准号:
23790681
负责人:
YANAGIBA Yukie
金额:
$2.5万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

项目摘要

项目成果

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相关文献

中文摘要
翻译
DMAC广泛用于制药和工业化学化合物。将cyp 2 e1 +/+和cyp 2 e1-/-小鼠暴露于吸入DMAC或载体对照(10、25、50和250 ppm)14天。在cyp 2 e1 +/+和cyp 2 e1-/-小鼠中,在50和250 ppm的DMAC下,血浆AST和ALT活性显著升高。两种基因型均观察到组织学改变。此外,高浓度暴露后,cyp 2 e1-/-细胞也出现局灶性坏死和脂肪变性。尿中NMAC和DMAC的阳性率分别为100%和100%。此外,与cyp 2 e1 +/+小鼠相比,NMAC和DMAC是高浓度的。乙酰胺染毒组小鼠尿中检测到CYP 2 E1 +/+。因此,大多数DMAC代谢通过CYP 2 E1进行,但这表明也可能存在其他途径。
英文摘要
DMAC is widely used in pharmaceutical and industrial chemical compounds. The cyp2e1+/+and cyp2e1-/- mice were exposed to inhalation of DMAC or vehicle control (10, 25, 50 and 250ppm) for 14 days., In cyp2e1+/+ and cyp2e1-/-mice, plasma AST and ALT activities were significantly increased at 50 and 250ppm of DMAC. The histological changes were observed in both genotypes. In addition, focal necrosis and fatty degeneration was also observed in the cyp2e1-/- at the high concentration exposure. cyp2e1-/- were detected in the exposed group for NMAC and DMAC in mice urine. Further, NMAC and DMAC was high concentration as compared to cyp2e1+/+ mice. cyp2e1+/+ were detected in the exposed group for acetamide in mice urine. Hence, most of the DMAC metabolism takes place via CYP2E1, but it is indicated that there is a possibility that other pathways also exist.
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会议论文
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [(柳場由絵), 須田恵, 王瑞生, 扇祖銓, 久保田久代, 北條理恵子, 那須民江]
通讯作者: 那須民江
Oxidative metabolism effects of inhalation exposure to dimethylacetamide
吸入二甲基乙酰胺对氧化代谢的影响
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: []
通讯作者:
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [(柳場由絵), 須田恵, 王瑞生, 久保田久代, 北條理恵子, 那須民江]
通讯作者: 那須民江
DMAC吸入曝露による肝臓における酸化ストレスの増加
DMAC 吸入暴露导致肝脏氧化应激增加
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [(柳場由絵), 須田恵, 王瑞生, 扇祖銓, 久保田久代, 北條理恵子, 那須民江]
通讯作者: 那須民江
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