Functional and qualitative analysis of cardiomyocytes derived frominduced pluripotent stem cells

诱导多能干细胞来源的心肌细胞的功能和定性分析

• 批准号: 23790877
• 负责人: OHNO Yohei
• 金额: $ 2.66万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790877/
• 关键词: iPS細胞; iPS細胞由来心筋細胞; iPS細胞由来心筋の分化誘導効率; 心臓再生療法; 人工多能性幹細胞; iPS細胞からの心筋分化

We analyzed the difference of cardiomyocyte (CM) differentiation derivedfrom mouse iPS cells. High-quality iPS cells which highly expressed stem cell markers withouttransgene expression showed better CM differentiation properties in terms of

分析了小鼠iPS细胞向心肌细胞分化的差异。高质量的iPS细胞，高表达干细胞标记物，而不表达转基因，在CM分化方面表现出更好的特性。

项目成果

Reasidual transgene expression of Yamanakafactors determine quality and differentiationefficiency of cardiomyocytes derived from mouseinduced pluripotent stem cell lines

山中因子的残留转基因表达决定小鼠诱导多能干细胞系来源的心肌细胞的质量和分化效率

• 发表时间: 2012
• 作者: Miyata M;Yoshihisa A;Yamaki T;Iwaya S;Owada T;Suzuki S;Oikawa M;Sugimoto K;Nakazato K;Suzuki H;Saitoh S;Takeishi Y;大野洋平
• 通讯作者: 大野洋平

Residual Transgene Expression Of Yamanaka Factors Determine Quality And Differentiation Efficiency Of Cardiomyocytes Derived From Mouse Induced Pluripotent Stem Cell Lines

山中因子的残留转基因表达决定小鼠诱导多能干细胞系来源的心肌细胞的质量和分化效率

• 发表时间: 2012
• 作者: Ohno Y;Yuasa S;Egashira T;Seki T;Hashimoto H;Tohyama S;Kodaira M;Kusumoto D;Hattori F;Yae K;Murata M;Fukuda K
• 通讯作者: Fukuda K