Roles of bone morphogenetic protein-6 inaldosterone regulation by adrenocortical cells

肾上腺皮质细胞骨形态发生蛋白-6醛固酮调节的作用

• 批准号: 23791058
• 负责人: TSUKAMOTO Naoko
• 金额: $ 2.66万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791058/
• 关键词: 内科学; 内分泌; 副腎; ステロイド; 成長因子; アルドステロン; BMP; エンドセリン

In the present study, we examined the in vivo roleof BMP-6 in regulation of aldosterone by neutralizing endogenous BMP-6 in rats treated with immunization against BMP-6. It was suggested that endogenous BMP-6 is functionally linked to aldosterone synthesis in the adrenal cortex in vivo.

在本研究中，我们研究了BMP-6在调节醛固酮中的体内作用，通过中和内源性BMP-6在用BMP-6免疫处理的大鼠中。提示内源性BMP-6在功能上与体内肾上腺皮质中的醛固酮合成相关。

项目成果

Mutual Regulation of Growth Hormone and Bone Morphogenetic Protein System in Steroidogenesis by Rat Granulosa Cells

• DOI: 10.1210/en.2011-1646
• 发表时间: 2012-01-01
• 期刊: ENDOCRINOLOGY
• 影响因子: 4.8
• 作者: Nakamura, Eri;Otsuka, Fumio;Makino, Hirofumi
• 通讯作者: Makino, Hirofumi

Enhanced expression of bone morphogenetic protein system in aldosterone-treated mouse kidneys

• DOI: 10.1038/hr.2011.186
• 发表时间: 2012-03
• 期刊: Hypertension Research
• 影响因子: 5.4
• 作者: J. Suzuki;F. Otsuka;Y. Matsumoto;K. Inagaki;T. Miyoshi;M. Takeda;Naoko Tsukamoto;Eri Nakamura;Kanako Ogura;H. Makino

Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LβT2 gonadotrope cells.

• DOI: 10.1016/j.mce.2011.08.001
• 发表时间: 2012-01-02
• 期刊: MOLECULAR AND CELLULAR ENDOCRINOLOGY
• 影响因子: 4.1
• 作者: Takeda, Masaya;Otsuka, Fumio;Takahashi, Hiroaki;Inagaki, Kenichi;Miyoshi, Tomoko;Tsukamoto, Naoko;Makino, Hirofumi;Lawson, Mark A.
• 通讯作者: Lawson, Mark A.

Functional interaction of bone morphogenetic protein and growth hormone releasing peptide in adrenocorticotropin regulation by corticotrope cells

• DOI: 10.1016/j.mce.2011.06.016
• 发表时间: 2011-09
• 期刊: Molecular and Cellular Endocrinology
• 影响因子: 4.1
• 作者: Naoko Tsukamoto;F. Otsuka;T. Miyoshi;K. Inagaki;Eri Nakamura;T. Terasaka;M. Takeda;T. Ogura;Y. Iwasaki;H. Makino

下垂体コルチコトロープにおけるACTH分泌制御機構:GHRP/CRHとBMP-4 の機能連関

垂体促肾上腺皮质激素的ACTH分泌控制机制：GHRP/CRH与BMP-4之间的功能关系

• 发表时间: 2012
• 作者: Takayama K;Misawa A;Urano T;Horie-Inoue K;Mano H;Ouchi Y;塚本尚子・三好智子・他
• 通讯作者: 塚本尚子・三好智子・他