Importance of Urinary Bone Resorptive Marker in Diagnosis and Classification of Osteogenesis Imperfecta

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We analyzed whether urinary N-telopeptide of type I collagen become a diagnostic marker of patients with infantile osteogenesi imperfecta. Urinary NTX value in OI patients is significantly lower than that of healthy infant although overlap between two groups was observed. In one month old, urinary NTX value in OI infants is significantly lower than healthy control without overlap and without relation to height and body weight. From these results, urinary NTX value at one month old might become a diagnostic marker of OI infants.