The effect of direct renin inhibitor in the progression of rat crescentic glomerulonephritis model

为了研究阿利吉伦是否能改善新月体肾炎(GN)大鼠的肾损伤，我们观察了阿利吉伦对新月体肾炎(GN)大鼠的肾脏损伤。结果，阿利吉伦减少了肾小球新月体和蛋白尿的百分比，也抑制了肾脏MCP-1的表达。这些数据提示，阿利吉仑的治疗策略可能通过激活RAS和减轻新月体GN的炎症而有益于新月体GN。

To examine whether aliskiren ameliorate renal injury in crescentic glomerulonephritis (GN), we investigated renal injury in rat crescentic GN model treated with aliskiren. As a result, aliskiren reduced % glomerular crescent and proteinuria, and also, aliskiren suppressed renal expression of MCP-1. These data suggest therapeutic strategy of aliskiren may prove beneficial for crescentic GN by the RAS activation and the decrease of inflammation in crescentic GN.