Structure of Sebosomes, secret membrane vesicles of cultured sebocytes

皮脂体的结构，培养皮脂细胞的分泌膜囊泡

• 批准号: 23791274
• 负责人: NAGAI Ayako
• 金额: $ 2.75万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791274/
• 关键词: セボゾーム; 脂腺細胞; ヒストン; 抗菌; 分泌膜小胞; Sebosomes; sebocytes

Rat cultured sebocytes synthesized and secreted sebosomes. The sebosomes contained multiple subcellular organelles such as exosomes, plasma membrane, endosomes, lysosomes, lipid particles and lipid rafts, suggesting that the secretory mechanism of the sebosomes was different from that of exosomes. Newly synthesized proteins including histones were detected both in the de novo synthesized sebosomes and nuclei in cultured sebocytes. It was suggested that the organelles were continuously and actively localized to the sebosomes. The sebosomes were suggested to supply multiple molecules, lipids and proteins to keratinocytes and surrounding cells.

培养的大鼠皮脂细胞合成和分泌脂质体。脂体含有外体、质膜、内体、溶酶体、脂粒和脂筏等多种亚细胞细胞器，提示脂体的分泌机制与外体不同。新合成的蛋白质，包括组蛋白，在新合成的脂质体和培养的皮脂细胞的细胞核中都能检测到。提示细胞器持续活跃地定位于脂小体。脂质体可能为角质形成细胞及周围细胞提供多种分子、脂类和蛋白质。

项目成果

Function of Sebosomes in Sebocytes "Supply Molecules to Surrounding Cells" (口頭発表)

皮脂细胞中皮脂体的功能“向周围细胞供应分子”（口头报告）

• 发表时间: 2011
• 作者: Ayako Nagai;Michihiro Sumida,
• 通讯作者: Michihiro Sumida,

Components of Sebosomes, membrane vesicles of sebocytes

皮脂体的成分，皮脂细胞的膜囊泡

• 发表时间: 2012
• 作者: 永井彩子;澄田道博
• 通讯作者: 澄田道博