The histological algorithm to discriminate mycosis fungoides from cutaneous ATL in HTLV1 carrier

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We aimed to establish the pathological algorithm to discriminate mycosis fungoides from cutaneous ATL in HTLV1 carrier.The differentiation by the expression of proteins such as FoxP3, RNA-editing enzymes, CXCR4 those are directly unrelated to carcinogenic mechanisms of ATL, were quite difficult and unreliable.Then, we tried to discover the indispensable specific microRNA to each lymphoma, and aimed at the analysis of the proteins controlled in the douwnstream in an early-phase lesion.To cutaneous ATL, I sorted out microRNA-146b, -5p, and-451, and -20a, 29a, 30b, 31,181a, 222, 320a to mycosis fungoides, respectively.By comparing the expressions of microRNAs before and behind the treatment by anti-CCR4 antibody, we are also advancing sorting of the more specific microRNAs.