Analyses of mechanism of the elevation of serum reactive oxidative metabolite level and expressions of related genes in an irradiated rat model

辐射大鼠模型血清反应性氧化代谢物水平及相关基因表达升高的机制分析

• 批准号: 23791389
• 负责人: NOMIYA Takuma
• 金额: $ 2.66万
• 依托单位: National Institute of Radiological Sciences (2012-2013)Yamagata University (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791389/
• 关键词: 放射線治療生物学; 放射線障害; フリーラジカル; 酸化ストレス; 動物実験; 放射線照射; 皮膚反応; 放射線

Recently, oxidative metabolites have been able to be measured by simple small device. Radiation used in radiotherapy causes free radicals and oxidative metabolites, and irradiation causes dermatitis and sometimes causes skin ulcer in the irradiated site. We analyzed the relationships among the value of oxidative metabolites and skin reactions and gene expressions. As a result, a significant correlation was seen between the value of oxidative metabolites and irradiation dose. And some genes (e.g. NOS2, NCF1, NCF2, etc.) were overexpressed after the irradiation. It was suggested that measuring the level of serum oxidative metabolites seems to be useful for estimating degree of skin reaction, and a part of reactions to the irradiation was revealed in the gene expression level.

近年来，氧化代谢物已经能够通过简单的小型装置进行测量。放射治疗中使用的辐射会产生自由基和氧化代谢物，照射会引起皮炎，有时会引起受照射部位的皮肤溃疡。我们分析了氧化代谢物值与皮肤反应和基因表达之间的关系。因此，氧化代谢物的值与辐照剂量之间存在显著的相关性。辐照后部分基因（如NOS2、NCF1、NCF2等）过表达。结果表明，测定血清氧化代谢物的水平可能有助于估计皮肤反应的程度，辐照反应的一部分反映在基因表达水平上。

项目成果

Relationship between the quantity of serum reactive oxygen metabolites and skin toxicity grade in the irradiated rat model

辐照大鼠模型血清活性氧代谢物含量与皮肤毒性等级的关系

• 发表时间: 2013
• 作者: Nomiya T;Kaneko T;Goto J;Harada M;Akamatsu H;Ota I;Hagiwara Y;Kamada T;Nemoto K.
• 通讯作者: Nemoto K.

Relationship between the quantity of serum reactive oxygen metabolites and skin toxicity grade in the irradiated rat model.

辐照大鼠模型血清活性氧代谢物含量与皮肤毒性等级的关系

• 发表时间: 2013
• 作者: Nomiya T;Kaneko T;Goto J;Harada M;Akamatsu H;Ota I;Hagiwara Y;Kamada T;Nemoto K.
• 通讯作者: Nemoto K.

Relationship between serum reactive oxidative metabolite level and skin reaction in an irradiated rat model

• DOI: 10.3109/10715762.2014.894637
• 发表时间: 2014-05-01
• 期刊: FREE RADICAL RESEARCH
• 影响因子: 3.3
• 作者: Nomiya, Takuma;Kaneko, Takashi;Nemoto, Kenji
• 通讯作者: Nemoto, Kenji