Creation of metal surface adhesive to soft tissue

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To immobilize collagen uniformly to titanium surface without self-assembly of collagen, electrodeposition technique with alternative current, repetition of anodic current and cathodic current charge, was the most effective. The soft tissue compatibility of titanium immobilized collagen was evaluated by cell culture of fibroblast. The results revealed that initial adhesion, expansion, and proliferation of cells were not inhibited on the surface. On the other hand, it was difficult to evaluate the bonding strength between soft tissue and substrate material. Further research to obtain reproducible and reliable evaluation of sft tissue compatibility protocol is necessary.