The role of SmgGDS in the pleiotropic effects by statins

我们验证了我们的假设，即小gtp结合蛋白GDP解离刺激剂（SmgGDS）在内皮细胞中3-羟基-3-甲基戊二酰辅酶a还原酶抑制剂（他汀类药物）抑制Rac1信号通路的分子机制中起着至关重要的作用。在本研究中，我们证明了他汀类药物通过上调SmgGDS发挥其多效作用，从而导致动物和人类的Rac1降解和氧化应激降低。

We tested our hypothesis that small GTP-binding protein GDP dissociation stimulator (SmgGDS) plays a crucial role in the molecular mechanisms of the Rac1 signaling pathway inhibition by3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) in endothelial cells. In the present study, we demonstrated that statins exert their pleiotropic effects through SmgGDS upregulation with a resultant Rac1 degradation and reduced oxidative stress in animals and humans.