The role of SmgGDS in the pleiotropic effects by statins

我们验证了我们的假设，即小GTP结合蛋白GDP解离刺激物(SmgGDS)在3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂(STATINS)抑制内皮细胞内RAC1信号通路的分子机制中起关键作用。在目前的研究中，我们证明了他汀类药物通过上调SmgGDS而在动物和人类中发挥多效性作用，从而导致rac1的降解和氧化应激的减少。

We tested our hypothesis that small GTP-binding protein GDP dissociation stimulator (SmgGDS) plays a crucial role in the molecular mechanisms of the Rac1 signaling pathway inhibition by3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) in endothelial cells. In the present study, we demonstrated that statins exert their pleiotropic effects through SmgGDS upregulation with a resultant Rac1 degradation and reduced oxidative stress in animals and humans.