Role of Rho/Rho-kinase-mediated pathway in the pathogenesls of atherosclerosis

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(1)We have demonstrated that Rho/Rho-kinase-mediated pathway plays an important role in the pathogenesis of hypertension.(2)We have demonstrated that Rho-kinase-mediated pathway is substantially involved in the pathogenesis of angiotensin II-induced cardiovascular hypertrophy in rats.(3)We have demonstrated that Rho-kinase is located downstream of PKC in the signal transduction of vascular smooth muscle for coronary spasm in a porcine model.(4)We have demonstrated that long-term treatment with a Rho-kinase inhibitor suppresses the development of in-stent restenosis in porcine coronary arteries.(5)We have demonstrated that long-term treatment with a Rho-kinase inhibitor suppresses the development of LV remodeling after myocardial infarction in mice through inhibition of the expression of inflammatory cytokines.(6)We have demonstrated that long-term treatment with a Rho-kinase inhibitor suppresses the development of monocrotaline-induced pulmonary hypertension in rats.(7)We have demonstrated that Rho-kinase is substantially mediated in the pathogenesis of microvascular angina.