Common and distinct mechanisms for ARF6-mediated neuronal migration and cancer invasion

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ADP ribosylation factor is a small GTPase that regulate membrane traffic and actin remodeling through the activation of lipid modifying enzymes and recruitment of various interacting proteins such as FIP3/4 and JIP3/4. Recent evidence indicates the functional importance of ARF6 pathways in cell motility such as cancer invasion and metastasis. The aim of this study is to test the possibility whether the ARF6 pathway may be involved in neuronal migration during cortical layer formation. We found that type I phosphatidylinositol 4-phosphate 5-kinase r (PIP5KIr), a phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)-synthesizing enzyme that functions as a downstream effector of Arf6, is required for neuronal migration possibly through recruitment of adhesion components to the plasma membrane.