Molecular mechanisms of TGF-b signaling for reprogramming
Molecular mechanisms of TGF-b signaling for reprogramming
批准号:
23659146
负责人:
ITOH Fumiko
金额:
$2.41万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
It is required for the improvement and process of establishment efficiency induced pluripotent stem (iPS) cells. Reprogramming of the cells involves an intermediate mesenchymal-epithelial transition (MET)-like process that is also regulated by TGF ss In this study, we have tried to find out the molecularmechanisms in MET process regulated by TGF-ss. We used mouse embryonic fibroblast (MEF) cells from TGF-b receptors conditional knockout mice crossing with CAG-Cre Tg mice. Then we generated iPS cellsfrom the MEF cells by lentivirus vectors which encode Nakayama factors under the control of doxycycline dependent expression system. These iPS cells showed clonal variety and required longer passage for stabilization.
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Dicer-dependent miRNA pathway is important for early hematopoiesis but not for angiogenesis.
Dicer 依赖性 miRNA 通路对于早期造血很重要,但对于血管生成则不重要。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[築山忠維, 畠山鎮次, Fumiko Itoh]
通讯作者:
Fumiko Itoh
別冊・医学のあゆみ TGF-βシグナル研究―メカニズムの解明からあらたな治療へ
另册:TGF-β信号研究的医学史——从阐明机制到新疗法
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[有岡 将基, 高橋 富美, 佐々木 匡理, 笹栗 俊之, 伊東 史子]
通讯作者:
伊東 史子
Dicer-dependent miRNA pathway is important for vascular development
Dicer 依赖性 miRNA 通路对血管发育很重要
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Itoh, F., Hazome, S., Fruttiger, M., Itoh, S., and Watanabe, T]
通讯作者:
T
血管新生と腫瘍血管、がんの増殖と悪性化の分子機構. 宮澤恵二、伊東進編
血管生成、肿瘤血管以及癌症生长和恶性肿瘤的分子机制,由 Keiji Miyazawa 和 Susumu Ito 编辑。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Otomo K, Atsumi T, Fujieda Y, Nakagawa H, Amengual O, Kato M, Horita T, Tasuda S, Matsumoto M, Hatakeyama S, Koike T., 伊東史子]
通讯作者:
伊東史子
血管新生と腫瘍血管、がんの増殖と悪性化の分子機構
血管生成与肿瘤血管、癌症生长和恶性转化的分子机制
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[伊東史子, 血管新生と腫瘍血管, 宮澤恵二, 伊東進編]
通讯作者:
伊東進編
共 16 条
The development of new treatment for endometriosis using non hormone therapy targeting intraperitoneal environment.
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批准号:15K20152
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.08万
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财政年份:2015
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负责人:ITOH Fumiko
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依托单位:
The role of TGF-b signaling in blood and lymph angiogenesis
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批准号:23689023
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项目类别:Grant-in-Aid for Young Scientists (A)
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资助金额:$6.66万
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财政年份:2011
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负责人:ITOH Fumiko
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依托单位:
The role of TGF-・・signaling in Angiogenesis
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批准号:21890022
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项目类别:Grant-in-Aid for Research Activity Start-up
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资助金额:$1.7万
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财政年份:2009
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负责人:ITOH Fumiko
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依托单位:
海外基金