Research on regulation and expression mechanisms of functionalglycans associated with congenital muscular dystrophy

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α-Dystroglycan undergoes extensive glycosylation required for the interaction between α-dystroglycan and the extracellular matrix such as laminin and aberrant glycosylation of α-DG has already been identified in the pathogenesis of several types of congenital muscular dystrophy. In this study, we revealed that a sulfotransferase, HNK-1ST, suppressed the glycosylation and reduced the ligand-binding activity of α-dystroglycan. We also found that HNK-1ST regulated the migration of melanoma cells through the glycosylation state on α-dystroglycan