Gain more insight, perform the following genome-wide association studies in Japanese, counterargument to the study that need correct re-diagnosis by Europe-an study

获得更多见解，用日语进行以下全基因组关联研究，反驳需要欧洲正确重新诊断的研究 - 一项研究

• 批准号: 23659160
• 负责人: TASHIRO Kei
• 金额: $ 2.41万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659160/
• 关键词: ゲノム医化学; 遺伝子; 落屑緑内障; GWAS; ゲノムワイド関連解析

We examined our two data sets of the genome-wide association studies (GWAS) derived from a Japanese population was strictly classified as glaucoma and controls with detail examination and diagnosis. We performed a GWAS by analyzing 653,519 autosomal common single-nucleotide polymorphisms (SNPs) in 833 POAG patients and 686 controls. We then subdivided the case groups into two subtypes based on the value of intraocular pressure (IOP) -POAG with high IOP (high Pressure glaucoma, HPG) and that with normal IOP (normal pressure glaucoma, NPG) performed the GWAS. The results suggested that the variants from CDKN2B-AS1 locus were likely to be significant for NPG patients （PLoS ONE: 7: e33389, 2012）.On the other hand we performed a case-control study using 190 Japanese exfoliation glaucoma (XFG) patients and 660 controls．It is currently under consideration of replication study of the association to identify specific marker for XFG.

我们检查了我们的两个数据集的全基因组关联研究（GWAS）来自日本人口严格分类为青光眼和控制与详细的检查和诊断。我们通过分析833例POAG患者和686例对照的653，519个常染色体常见单核苷酸多态性（SNP）进行了GWAS。然后根据眼压值将病例组分为两个亚型-高眼压POAG（HPG）和正常眼压POAG（NPG）进行GWAS。结果表明，CDKN 2B-AS 1位点的变异可能对NPG患者有意义（PLoS ONE：7：e33389，2012）。另一方面，我们对190例日本剥脱性青光眼（XFG）患者和660例对照进行了病例对照研究，目前正在考虑进行相关性的复制研究，以确定XFG的特异性标志物。

项目成果

溶血法を用いたEBウイルス細胞株の簡易迅速樹立法の検討

溶血法建立EB病毒细胞系的简单快速方法的检验

• 发表时间: 2011
• 作者: 大見奈津江;徳田雄市;足立博子;池田陽子;上野盛夫;森和彦;中野正和;木下茂;田代啓.
• 通讯作者: 田代啓.

Association Between General Systematic Disease and the Marker Snps for Primary Open-Angle Glaucoma

一般系统性疾病与原发性开角型青光眼标记 Snps 之间的关联

• 发表时间: 2010
• 作者: Ikeda Y;Mori K;Ueno M;Imai K;Yagi T;Omi N;Tokuda Y;Fuwa M;Tashiro K;Kinoshita S.
• 通讯作者: Kinoshita S.

Association of risk alleles of glaucoma marker SNPs with morphological characters of the optic disc

青光眼标记 SNP 的风险等位基因与视盘形态特征的关联

• 发表时间: 2012
• 作者: Ikeda Y; Mori K;Ueno M;Imai K;Nakano M;Fuwa M;Yoshii K;Yagi Y;Tokuda Y;Tashiro K;and Kinoshita S
• 通讯作者: and Kinoshita S

緑内障の検査診断学

青光眼测试和诊断

• 发表时间: 2011
• 作者: 池田陽子;中野正和;田代啓;森和彦;木下茂
• 通讯作者: 木下茂

The defects of Sfrp2 reveal modulating calcium signaling in lymphocytes.

Sfrp2 的缺陷揭示了淋巴细胞中钙信号传导的调节。

• 发表时间: 2013
• 作者: 徳田雄市;田中雅深;八木知人;田代啓
• 通讯作者: 田代啓