Gain more insight, perform the following genome-wide association studies in Japanese, counterargument to the study that need correct re-diagnosis by Europe-an study

我们检查了我们的两个数据集的全基因组关联研究（GWAS）来自日本人口严格分类为青光眼和控制与详细的检查和诊断。我们通过分析833例POAG患者和686例对照的653，519个常染色体常见单核苷酸多态性（SNP）进行了GWAS。然后根据眼压值将病例组分为两个亚型-高眼压POAG（HPG）和正常眼压POAG（NPG）进行GWAS。结果表明，CDKN 2B-AS 1位点的变异可能对NPG患者有意义（PLoS ONE：7：e33389，2012）。另一方面，我们对190例日本剥脱性青光眼（XFG）患者和660例对照进行了病例对照研究，目前正在考虑进行相关性的复制研究，以确定XFG的特异性标志物。

We examined our two data sets of the genome-wide association studies (GWAS) derived from a Japanese population was strictly classified as glaucoma and controls with detail examination and diagnosis. We performed a GWAS by analyzing 653,519 autosomal common single-nucleotide polymorphisms (SNPs) in 833 POAG patients and 686 controls. We then subdivided the case groups into two subtypes based on the value of intraocular pressure (IOP) -POAG with high IOP (high Pressure glaucoma, HPG) and that with normal IOP (normal pressure glaucoma, NPG) performed the GWAS. The results suggested that the variants from CDKN2B-AS1 locus were likely to be significant for NPG patients （PLoS ONE: 7: e33389, 2012）.On the other hand we performed a case-control study using 190 Japanese exfoliation glaucoma (XFG) patients and 660 controls．It is currently under consideration of replication study of the association to identify specific marker for XFG.