Generation of claudin targeted autoimmune disease mouse model

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Autoimmune diseases, in which tissues of the body are pathologically attacked by an individual`s own immune system, are presently difficult to cure completely. Autoimmunogens are suggested to exist in almost all known autoimmune diseases, but their identity is not known in many cases. Notably, many autoimmune diseases are accompanied by inflammation in epithelial tissues. In this project, we propose that claudin, a major tight junction protein, is a target immunogen in some autoimmune diseases. To clarify the relationship between claudin and autoimmune diseases, we sought to generate a claudin-targeted autoimmune disease mouse model.