Discovery of intramitochondrial lysosome

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In this study, we obtained several important findings on the mechanism for induction of the intramitochondrial lysosome. First, BNIP3 and NIX, two mitochondrial outer membrane proteins, play a pivotal role in induction of the intramitochondrial lysosome. The interaction of Mieap, BNIP3 and NIX at mitochondrial outer membrane induces the opening of a pore in the mitochondrial double membrane. Surprisingly, this is completely unrelated to cell death. Second, 14-3-3gamma interacts with Mieap and is translocated into mitochondria. Intramitochondrial 14-3-3gamma plays a critical role in the elimination of oxidized mitochondrial proteins. These results suggest that the opening of a pore in the mitochondrial double membrane and an adaptor protein are very substantial in the mechanism for the intramitochondrial lysosome.