Identification and characterization of p53-target genes

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In the present study, we identified and characterized seven novel p53-target genes ; DFNA5, SEMA3F, BLNK, UNC5A, TMPS, NEEP21 and Mieap. DFNA5, UNC5A, TMPS and NEEP21 are involved in p53-dependent apoptosis. SEMA3F is a mediator of p53-regulated anti-angiogenesis. Discovery of these genes could provide more information to two major functions of p53 ; cell death and anti-angiogenesis. On the other hand, discovery of BLNK and Mieap demonstrates that there are very novel pathways for p53 tumor suppression. BLNK prevents aneuploidy by inhibiting cytokinesis after DNA damage, leading to maintenance of genomic stability. Moreover, Mieap plays an essential role in mitochondrial quality control. These findings could not only shed light on the mechanism of p53 tumor suppression but also contribute to understanding of cancer nature.