Study on the molecular mechanism of Salmonella pathogenicity using a target・edge-oriented screening of effectors

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A broad range of pathogenic bacteria translocate a repertoire of effector proteins using the type III protein secretion system and enact the virulence program of the bacteria by directly interacting with host cell pathways. The effectors do not have well-conserved sequence and do not have any kind of common identifiable signal sequence to target them for secretion. This makes it very difficult to identify novel effectors. In this study, we have established a novel system to support the functional analysis of virulence effector, in which the function can be analyzed from the side of host factor in target pathway or from the host's protein-protein interaction targeted by virulence effector. In this system, the function of virulence effector can be predicted and assumed function can be assessed based on the mimicry features widely observedin most of virulence effectors.