Study of novel HIV restriction factors

越来越多的证据表明，宿主细胞具有内在的抗病毒因子。SAMHD1是一种新发现的抗HIV宿主因子，具有dNTP三磷酸水解酶活性，可耗尽未分裂髓系细胞内的dNTP池。由于DNA病毒利用细胞dNTPs，我们研究了SAMHD1是否限制了DNA病毒在未分裂的髓系靶细胞中的复制。事实上，双链DNA病毒，1型单纯疱疹病毒，受到SAMHD1的限制，以dNTP依赖的方式不分裂靶细胞。这项研究表明，SAMHD1是一种潜在的先天抗病毒玩家，它可以抑制多种DNA病毒的复制，以及在感染过程中感染未分裂的髓系细胞的逆转录病毒。

Accumulating evidences have suggested that the host cells possess intrinsic anti-viral factors. SAMHD1 is a newly identified anti-HIV host factor that has a dNTP triphosphohydrolase activity and depletes intracellular dNTP pools in non-dividing myeloid cells. Since DNA viruses utilize cellular dNTPs, we investigated whether SAMHD1 limits the replication of DNA viruses in non-dividing myeloid target cells. Indeed, a double stranded DNA viruses, herpes simplex virus type 1, are subject to SAMHD1 restriction in non-dividing target cells in a dNTP dependent manner. This study suggests that SAMHD1 is a potential innate anti-viral player that suppresses the replication of a wide range of DNA viruses as well as retroviruses that infect non-dividing myeloid cells during infection.