Development of inhaled therapy with anti-fibrotic peptides for pulmonary fibrosis

我们合成了能够抑制小鼠PDGF-BB与PDGFRβ结合的新型多肽。从这些多肽中，我们鉴定出对体外培养的肺成纤维细胞有较强抑制作用的3号多肽。在荧光显微镜下，FAM标记的3号肽与肺成纤维细胞强烈结合。3号肽吸入治疗可减少博莱霉素诱导的小鼠肺纤维化。这些结果表明，该多肽可能是一种新的、有前途的肺纤维化治疗药物。

We synthesized novel peptides which could inhibit the binding of mouse PDGF-BB to PDGFRbeta. From these peptides, we identified the peptide No.3 showing the strong inhibitory effects of the proliferation of lung fibroblasts in vitro. The FAM-labelled peptide No. 3 strongly bound to lung fibroblasts under a fluorescence microscopy. The administration of peptide No.3 as an inhaled therapy reduced bleomycin-induced lung fibrosis in mice. These results suggest that the peptide might be a novel and promising therapeutic agent for pulmonary fibrosis.