Inhibition of migration of bone marrow-derived fibrocytes : a role of PDGF and development of therapy for pulmonary fibrosis

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We hypothesized that PDGF might directly contribute to the migration of fibrocytes to the injured lungs, which inhibited by the blocking of PDGF receptor. Both human and murine fibrocytes expressed PDGF receptors・and・. PDGF proteins strongly stimulated the migration of both human and murine fibrocytes, and their migration was blocked by treatment with anti-PDGF receptor antibodies or imatinib in vitro. Furthermore, the number of fibrocytes in the lungs was significantly reduced by administration of anti-PDGFR・antibody and imatinib in bleomycin-induced pulmonary fibrosis in mice. These results suggest that PDGF receptor expressed in circulating fibrocytes contribute to their trafficking into the lungs.