Mechanism by which the pathogenesis of Parkinson's disease is stimulated by Gaucher's mutation.

戈谢突变刺激帕金森病的发病机制。

• 批准号: 23659462
• 负责人: HASHIMOTO Makoto
• 金额: $ 2.08万
• 依托单位: Tokyo Metropolitan Institute of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659462/
• 关键词: シヌクレイン; パーキンソン病; ゴーシェ病; リソソーム; オートファゴソーム

We observed that axonal globules are formed in both αsynuclein (αS)- and P123H Βsynuclein (βS) transgenic mice. Lysosomal pathology was similarly observed for both αS- and P123H βS-globules, while oxidative stress was associated with the αS-globules, and to a lesser extent with the P123H βS-globules. Other pathologies, such as mitochondrial alteration and LRRK2 accumulation, were exclusively detected for αS-globules. Collectively, both αS- and P123H βS-globules were formed through similar but distinct pathogenic mechanisms.

我们观察到α突触核蛋白(αS)-和P123H Βsynuclein （βS）转基因小鼠均形成轴突小球。αS-和P123H β s -球的溶酶体病理相似，氧化应激与αS-球相关，与P123H β s -球相关程度较低。其他病理，如线粒体改变和LRRK2积累，仅检测α - s球。总的来说，αS-和P123H β s -球是通过相似但不同的致病机制形成的。

项目成果

Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein.

• DOI: 10.1186/1756-6606-5-34
• 发表时间: 2012-09-26
• 期刊: Molecular brain
• 影响因子: 3.6
• 作者: Sekigawa A;Fujita M;Sekiyama K;Takamatsu Y;Hatano T;Rockenstein E;La Spada AR;Masliah E;Hashimoto M
• 通讯作者: Hashimoto M

Alzheimer's Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets. (Suzanne De La Monte, Ed.)

阿尔茨海默病发病机制-核心概念、转变范式和治疗目标。

• 发表时间: 2011
• 作者: Sekigawa A;Fujita M;Sekiyama K;Takamatsu Y;Wei J;Hashimoto M.
• 通讯作者: Hashimoto M.

Mechanism of axonal globule formation in a mouse model of α-synucleinopathy is distinct from thatin a mouse model of β-synucleinopathy

α-突触核蛋白病小鼠模型中轴突小球形成的机制与 β-突触核蛋白病小鼠模型中的轴突小球形成机制不同

• 发表时间: 2012
• 作者: 関川明生 関山一成;藤田雅代;高松芳樹;橋本款
• 通讯作者: 橋本款

Dual effects of β-synuclein on the pathogenesis of Parkinson's disease

β-突触核蛋白对帕金森病发病机制的双重作用

• 发表时间: 2013
• 期刊: Ann Neurol
• 影响因子: 11.2
• 作者: Sekigawa A;Sekiyama K;Takamatsu Y;Fujita M;Hashimoto M
• 通讯作者: Hashimoto M

エルドバ誘発性ジスキネジアと大脳基底核におけるシヌクレイン病理の関連性

埃尔多巴诱发的运动障碍与基底节突触核蛋白病理之间的关联

• 发表时间: 2012
• 作者: Kurokawa;R.;Li PK;橋本款
• 通讯作者: 橋本款