Establishment and dynamism of des-HMGB1, degraded HMGB1 by thrombin-thrombomodulin

des-HMGB1、凝血酶-血栓调节蛋白降解的 HMGB1 的建立和动态

基本信息

  • 批准号:
    23659491
  • 负责人:
  • 金额:
    $ 2.5万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 财政年份:
    2011
  • 资助国家:
    日本
  • 起止时间:
    2011 至 无数据
  • 项目状态:
    已结题

项目摘要

We previously showed that HMGB1 binds to thrombomodulin(TM) and degraded by thrombin-TM at the N-terminus of the molecule cleaving out 10 aminoacdid-residue. We named this degraded HMGB1 as des-HMGB1. We also have showed that des-HMGB1 compete with intact binding to its receptor RAGE, Toll-like receptor-2 and-4 resulting negatively regulating of intact HMGB1 and its receptor signaling.In this study, we established the des-HMGB1 specific assay ELISA, and investigated its dynamism in various diseases including DIC, sepsis and shock. We showed that the des-HMGB1 was increased in the serum from the patients with these pathologic conditions, especially in the cases treated with recombinant TM. We are now further studying relationship between des-HMGB1 levels and the efficacy of TM treatment and their prognosis.
我们以前发现HMGB 1与血栓调节蛋白(TM)结合,并在分子的N-末端被凝血酶-TM降解,切割出10个氨基酸残基。我们将这种降解的HMGB 1命名为des-HMGB 1。本研究建立了des-HMGB 1特异性ELISA检测方法,并研究了des-HMGB 1在DIC、脓毒症和休克等疾病中的动态变化。我们发现,des-HMGB 1在这些病理条件的患者血清中增加,特别是在重组TM治疗的病例中。我们正在进一步研究des-HMGB 1水平与TM治疗效果及其预后的关系。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Prediction of the neurological outcome with intrathecal high mobility group box 1 and S100B in cardiac arrest victims: A pilot study
  • DOI:
    10.1016/j.resuscitation.2012.01.030
  • 发表时间:
    2012-08-01
  • 期刊:
  • 影响因子:
    6.5
  • 作者:
    Oda, Yasutaka;Tsuruta, Ryosuke;Maekawa, Tsuyoshi
  • 通讯作者:
    Maekawa, Tsuyoshi
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MARUYAMA Ikuro其他文献

MARUYAMA Ikuro的其他文献

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{{ truncateString('MARUYAMA Ikuro', 18)}}的其他基金

Cellular and molecular mechanism of blood sludging/skimming. Causative role of cancer exosomes and their pathophysiological view points
血液淤泥/撇渣的细胞和分子机制。
  • 批准号:
    18K19587
  • 财政年份:
    2018
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
Novel therapeutic proposal for DIC/Shock: from Damage-Sensing/-Control to Damage Resolution
DIC/休克的新颖治疗方案:从损伤感知/控制到损伤解决
  • 批准号:
    17H04363
  • 财政年份:
    2017
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Pathophysiological significance of two types of DAMPs, naked- and exosomal type.
裸露型和外泌体型两种 DAMP 的病理生理学意义。
  • 批准号:
    16K15763
  • 财政年份:
    2016
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Proposal of novel concept, Exosome cargo as a novel DAMPs delivery system
提出新概念,外泌体货物作为新型 DAMP 递送系统
  • 批准号:
    15K15667
  • 财政年份:
    2015
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Multi-layered and topological regulatory system of PAMPs and DAMPs. Its relevance in various pathophysiology.
PAMPs和DAMPs的多层拓扑调控系统。
  • 批准号:
    26293385
  • 财政年份:
    2014
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
PAMPs, DAMPs regulation by thrombomodulin(TM). Probable role of epithelial TM
PAMP、DAMP 由血栓调节蛋白 (TM) 调节。
  • 批准号:
    26670790
  • 财政年份:
    2014
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Localization and regulation in reactive sites of DAMPs/PAMPs. Role of ATP from the activated plateles
DAMPs/PAMPs 反应位点的定位和调节。
  • 批准号:
    25670764
  • 财政年份:
    2013
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Comprehensive regulatory system of PAMPs/DAMPs by TM-PC/EPCR system
TM-PC/EPCR 系统对 PAMPs/DAMPs 的综合调控体系
  • 批准号:
    24659798
  • 财政年份:
    2012
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Cellular mechanism in thrombin mediated HMGB1 release. Effect of cluster formation of HMGB1 on the cell-surface receptors.
凝血酶介导 HMGB1 释放的细胞机制。
  • 批准号:
    23390412
  • 财政年份:
    2011
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Defense system by thrombin-HMGB1 axis
凝血酶-HMGB1轴的防御系统
  • 批准号:
    20390274
  • 财政年份:
    2008
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
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