Establishment and dynamism of des-HMGB1, degraded HMGB1 by thrombin-thrombomodulin
des-HMGB1、凝血酶-血栓调节蛋白降解的 HMGB1 的建立和动态
基本信息
- 批准号:23659491
- 负责人:
- 金额:$ 2.5万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Challenging Exploratory Research
- 财政年份:2011
- 资助国家:日本
- 起止时间:2011 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We previously showed that HMGB1 binds to thrombomodulin(TM) and degraded by thrombin-TM at the N-terminus of the molecule cleaving out 10 aminoacdid-residue. We named this degraded HMGB1 as des-HMGB1. We also have showed that des-HMGB1 compete with intact binding to its receptor RAGE, Toll-like receptor-2 and-4 resulting negatively regulating of intact HMGB1 and its receptor signaling.In this study, we established the des-HMGB1 specific assay ELISA, and investigated its dynamism in various diseases including DIC, sepsis and shock. We showed that the des-HMGB1 was increased in the serum from the patients with these pathologic conditions, especially in the cases treated with recombinant TM. We are now further studying relationship between des-HMGB1 levels and the efficacy of TM treatment and their prognosis.
我们之前发现HMGB1与血栓调节素(TM)结合,并在分子的n端被血栓调节素降解,并切割出10个氨基酸残基。我们将这种降解的HMGB1命名为des-HMGB1。我们还发现,des-HMGB1与其受体RAGE、toll样受体2和4的完整结合竞争,导致完整HMGB1及其受体信号传导的负调控。在本研究中,我们建立了des-HMGB1特异性ELISA,并研究了其在DIC、脓毒症和休克等多种疾病中的动态。我们发现,具有这些病理条件的患者血清中des-HMGB1升高,特别是在重组TM治疗的患者中。我们正在进一步研究des-HMGB1水平与TM治疗疗效及预后的关系。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Prediction of the neurological outcome with intrathecal high mobility group box 1 and S100B in cardiac arrest victims: A pilot study
- DOI:10.1016/j.resuscitation.2012.01.030
- 发表时间:2012-08-01
- 期刊:
- 影响因子:6.5
- 作者:Oda, Yasutaka;Tsuruta, Ryosuke;Maekawa, Tsuyoshi
- 通讯作者:Maekawa, Tsuyoshi
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MARUYAMA Ikuro其他文献
MARUYAMA Ikuro的其他文献
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{{ truncateString('MARUYAMA Ikuro', 18)}}的其他基金
Cellular and molecular mechanism of blood sludging/skimming. Causative role of cancer exosomes and their pathophysiological view points
血液淤泥/撇渣的细胞和分子机制。
- 批准号:
18K19587 - 财政年份:2018
- 资助金额:
$ 2.5万 - 项目类别:
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Novel therapeutic proposal for DIC/Shock: from Damage-Sensing/-Control to Damage Resolution
DIC/休克的新颖治疗方案:从损伤感知/控制到损伤解决
- 批准号:
17H04363 - 财政年份:2017
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$ 2.5万 - 项目类别:
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16K15763 - 财政年份:2016
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$ 2.5万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Proposal of novel concept, Exosome cargo as a novel DAMPs delivery system
提出新概念,外泌体货物作为新型 DAMP 递送系统
- 批准号:
15K15667 - 财政年份:2015
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Multi-layered and topological regulatory system of PAMPs and DAMPs. Its relevance in various pathophysiology.
PAMPs和DAMPs的多层拓扑调控系统。
- 批准号:
26293385 - 财政年份:2014
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
PAMPs, DAMPs regulation by thrombomodulin(TM). Probable role of epithelial TM
PAMP、DAMP 由血栓调节蛋白 (TM) 调节。
- 批准号:
26670790 - 财政年份:2014
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Localization and regulation in reactive sites of DAMPs/PAMPs. Role of ATP from the activated plateles
DAMPs/PAMPs 反应位点的定位和调节。
- 批准号:
25670764 - 财政年份:2013
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Comprehensive regulatory system of PAMPs/DAMPs by TM-PC/EPCR system
TM-PC/EPCR 系统对 PAMPs/DAMPs 的综合调控体系
- 批准号:
24659798 - 财政年份:2012
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Cellular mechanism in thrombin mediated HMGB1 release. Effect of cluster formation of HMGB1 on the cell-surface receptors.
凝血酶介导 HMGB1 释放的细胞机制。
- 批准号:
23390412 - 财政年份:2011
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Defense system by thrombin-HMGB1 axis
凝血酶-HMGB1轴的防御系统
- 批准号:
20390274 - 财政年份:2008
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
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