Establishment and dynamism of des-HMGB1, degraded HMGB1 by thrombin-thrombomodulin

des-HMGB1、凝血酶-血栓调节蛋白降解的 HMGB1 的建立和动态

基本信息

  • 批准号:
    23659491
  • 负责人:
  • 金额:
    $ 2.5万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 财政年份:
    2011
  • 资助国家:
    日本
  • 起止时间:
    2011 至 无数据
  • 项目状态:
    已结题

项目摘要

We previously showed that HMGB1 binds to thrombomodulin(TM) and degraded by thrombin-TM at the N-terminus of the molecule cleaving out 10 aminoacdid-residue. We named this degraded HMGB1 as des-HMGB1. We also have showed that des-HMGB1 compete with intact binding to its receptor RAGE, Toll-like receptor-2 and-4 resulting negatively regulating of intact HMGB1 and its receptor signaling.In this study, we established the des-HMGB1 specific assay ELISA, and investigated its dynamism in various diseases including DIC, sepsis and shock. We showed that the des-HMGB1 was increased in the serum from the patients with these pathologic conditions, especially in the cases treated with recombinant TM. We are now further studying relationship between des-HMGB1 levels and the efficacy of TM treatment and their prognosis.
我们之前发现HMGB1与血栓调节素(TM)结合,并在分子的n端被血栓调节素降解,并切割出10个氨基酸残基。我们将这种降解的HMGB1命名为des-HMGB1。我们还发现,des-HMGB1与其受体RAGE、toll样受体2和4的完整结合竞争,导致完整HMGB1及其受体信号传导的负调控。在本研究中,我们建立了des-HMGB1特异性ELISA,并研究了其在DIC、脓毒症和休克等多种疾病中的动态。我们发现,具有这些病理条件的患者血清中des-HMGB1升高,特别是在重组TM治疗的患者中。我们正在进一步研究des-HMGB1水平与TM治疗疗效及预后的关系。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Prediction of the neurological outcome with intrathecal high mobility group box 1 and S100B in cardiac arrest victims: A pilot study
  • DOI:
    10.1016/j.resuscitation.2012.01.030
  • 发表时间:
    2012-08-01
  • 期刊:
  • 影响因子:
    6.5
  • 作者:
    Oda, Yasutaka;Tsuruta, Ryosuke;Maekawa, Tsuyoshi
  • 通讯作者:
    Maekawa, Tsuyoshi
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

MARUYAMA Ikuro其他文献

MARUYAMA Ikuro的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('MARUYAMA Ikuro', 18)}}的其他基金

Cellular and molecular mechanism of blood sludging/skimming. Causative role of cancer exosomes and their pathophysiological view points
血液淤泥/撇渣的细胞和分子机制。
  • 批准号:
    18K19587
  • 财政年份:
    2018
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
Novel therapeutic proposal for DIC/Shock: from Damage-Sensing/-Control to Damage Resolution
DIC/休克的新颖治疗方案:从损伤感知/控制到损伤解决
  • 批准号:
    17H04363
  • 财政年份:
    2017
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Pathophysiological significance of two types of DAMPs, naked- and exosomal type.
裸露型和外泌体型两种 DAMP 的病理生理学意义。
  • 批准号:
    16K15763
  • 财政年份:
    2016
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Proposal of novel concept, Exosome cargo as a novel DAMPs delivery system
提出新概念,外泌体货物作为新型 DAMP 递送系统
  • 批准号:
    15K15667
  • 财政年份:
    2015
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Multi-layered and topological regulatory system of PAMPs and DAMPs. Its relevance in various pathophysiology.
PAMPs和DAMPs的多层拓扑调控系统。
  • 批准号:
    26293385
  • 财政年份:
    2014
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
PAMPs, DAMPs regulation by thrombomodulin(TM). Probable role of epithelial TM
PAMP、DAMP 由血栓调节蛋白 (TM) 调节。
  • 批准号:
    26670790
  • 财政年份:
    2014
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Localization and regulation in reactive sites of DAMPs/PAMPs. Role of ATP from the activated plateles
DAMPs/PAMPs 反应位点的定位和调节。
  • 批准号:
    25670764
  • 财政年份:
    2013
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Comprehensive regulatory system of PAMPs/DAMPs by TM-PC/EPCR system
TM-PC/EPCR 系统对 PAMPs/DAMPs 的综合调控体系
  • 批准号:
    24659798
  • 财政年份:
    2012
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Cellular mechanism in thrombin mediated HMGB1 release. Effect of cluster formation of HMGB1 on the cell-surface receptors.
凝血酶介导 HMGB1 释放的细胞机制。
  • 批准号:
    23390412
  • 财政年份:
    2011
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Defense system by thrombin-HMGB1 axis
凝血酶-HMGB1轴的防御系统
  • 批准号:
    20390274
  • 财政年份:
    2008
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)

相似海外基金

Exploring the role of extravascular factor IX in hemostasis in hemophilia B
探讨血管外因子 IX 在血友病 B 止血中的作用
  • 批准号:
    479270
  • 财政年份:
    2023
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Operating Grants
A new interpretation of contact activation system: A host defense mechanism for hemostasis and infection control
接触激活系统的新解释:止血和感染控制的宿主防御机制
  • 批准号:
    23H02383
  • 财政年份:
    2023
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Analysis of Whole Genome Sequence and Hemostasis Phenotypes
全基因组序列和止血表型分析
  • 批准号:
    10654394
  • 财政年份:
    2023
  • 资助金额:
    $ 2.5万
  • 项目类别:
Hemostasis irradiation for advanced gastric cancer: elucidation of prognostic factors using a multifaceted approach
晚期胃癌的止血照射:采用多方面方法阐明预后因素
  • 批准号:
    22K07678
  • 财政年份:
    2022
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of a non-Factor small molecule, oral, prophylactic and hemostasis balanced therapy for treatment of clotting disorders including hemophilia A/B
开发非因子小分子、口服、预防性和止血平衡疗法,用于治疗包括血友病 A/B 在内的凝血障碍
  • 批准号:
    10384995
  • 财政年份:
    2022
  • 资助金额:
    $ 2.5万
  • 项目类别:
Hemostasis, Hematoma Expansion, and Outcomes After Intracerebral Hemorrhage
脑出血后的止血、血肿扩张和结果
  • 批准号:
    10598712
  • 财政年份:
    2022
  • 资助金额:
    $ 2.5万
  • 项目类别:
On-site Wound Clinics: A Multifunctional Hydrogel Bioadhesive for Instant Hemostasis, Rapid Wound Closure and Intelligent Healing
现场伤口诊所:用于即时止血、快速闭合伤口和智能愈合的多功能水凝胶生物粘合剂
  • 批准号:
    557493-2021
  • 财政年份:
    2022
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Postdoctoral Fellowships
Exploring the role of extravascular factor IX in hemostasis in hemophilia B
探讨血管外因子 IX 在血友病 B 止血中的作用
  • 批准号:
    477302
  • 财政年份:
    2022
  • 资助金额:
    $ 2.5万
  • 项目类别:
    Operating Grants
2022 Hemostasis Gordon Research Conference and Seminar
2022戈登止血研究会议暨研讨会
  • 批准号:
    10468359
  • 财政年份:
    2022
  • 资助金额:
    $ 2.5万
  • 项目类别:
Inhibiting biomechanical platelet aggregation to prevent arterial thrombosis without compromising hemostasis
抑制生物力学血小板聚集以预防动脉血栓形成而不影响止血
  • 批准号:
    10543714
  • 财政年份:
    2022
  • 资助金额:
    $ 2.5万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了