Development of a new phototherapy based on the biological effects of wavelength

基于波长生物效应的新型光疗法的开发

• 批准号: 23659552
• 负责人: MORITA Akimichi
• 金额: $ 2.33万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659552/
• 关键词: 光線療法; 免疫抑制; 制御性 T 細胞; TH17; UVA1; 制御性Ｔ細胞; 制御性T細胞

For the treatment of allergic and autoimmune diseases, the antigen-specific tolerance is needed for not only remission but also the cure of these diseases. In this application, we have analyzed the biological effects of UVB and UVA. Concomitantly, UVA1-LED device has been also developed. In the clinical application, PUVA and narrow-band UVB reduced the pathogenically relevant cells, TH17 and induced regulatory T cells successfully.

对于过敏性和自身免疫性疾病的治疗，抗原特异性耐受不仅是缓解而且是治愈这些疾病所必需的。在这个应用中，我们分析了UVB和UVA的生物效应。与此同时，UVA 1-LED器件也被开发出来。在临床应用中，PUVA和窄谱UVB成功地减少了致病相关细胞、TH 17和诱导调节性T细胞。

项目成果

Phototherapy reduces serum resistin levels of psoriasis patients

光疗降低银屑病患者血清抵抗素水平

• 发表时间: 2011
• 期刊: Photoderm Photoimmunol Photomedicin
• 作者: Kana Kawashima;Kan Torii;Takuya Furuhashi;Chiyo Saito;Eiichi Nishio;Emi Nishida;Yoichi Shintani;Akimichi Morita
• 通讯作者: Akimichi Morita

Photo (chemo)therapy reduces circulating Th17 cells and restores dysfunctional regulatory T cells in psoriasis.

光（化疗）疗法可减少银屑病中循环 Th17 细胞并恢复功能失调的调节性 T 细胞。

• 发表时间: 2012
• 作者: Takuya Furuhashi;Chiyo Saito;Kan Torii;Emi Nishida;Akimichi Morita
• 通讯作者: Akimichi Morita

Dual action operative mechanisms of phototherapy-the induction of apoptosis and regulatory T cells

光疗的双重作用机制——诱导凋亡和调节性T细胞

• 发表时间: 2012
• 作者: Kan Torii;Takuya Furuhashi;Chiyo Saito;Hiroshi Kato;Akiko Nishioka;Emi Nishida;Yoichi Shintani;and Akimichi Morita;Akimichi Morita
• 通讯作者: Akimichi Morita

Tobacco smoke is related to Th17 generation with clinical implications for psoriasis patients

• DOI: 10.1111/j.1600-0625.2010.01224.x
• 发表时间: 2011-04-01
• 期刊: EXPERIMENTAL DERMATOLOGY
• 影响因子: 3.6
• 作者: Torii, Kan;Saito, Chiyo;Morita, Akimichi
• 通讯作者: Morita, Akimichi

Monotherapy for vitiligo treatment using a 308-nm xenon-chloride excimer laser: colorimetry to assess the factor influencing the efficacy of this treatment in Asian patients

使用 308 nm 氯化氙准分子激光单一疗法治疗白癜风：通过比色法评估影响亚洲患者治疗效果的因素

• DOI: 10.1111/j.1346-8138.2012.01633.x
• 发表时间: 2012
• 期刊: J Dermatol
• 影响因子: 3.1
• 作者: Reiko Noborio;Motoki Nakamura;Misako Yoshida;Reiko Nakamura;Rieko Ooshima;Ryoji Kubo;Hiroshi Kato ;Akimichi Morita
• 通讯作者: Akimichi Morita