Study for the establishment of the treatment to promote skin maturation in preterm labor infants

促进早产儿皮肤成熟治疗方法建立的研究

• 批准号: 23659781
• 负责人: SUGINO Norihiro
• 金额: $ 2.33万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659781/
• 关键词: 皮膚; SCC; 扁平上皮; E－カドヘリン; モーカドヘリン; カルシウム; 扁平上皮細胞; カドヘリン; インボルクリン

This study was undertaken to investigate whether squamous cell carcinoma antigen (SCCA), which is well known as a tumor marker of SCC, has the abilities to stimulate production of cell-to-cell adhesion molecules and to maintain the structure of squamous epithelium. Expression of E-cadherin, a cell-to-cell adhesion molecule, was increased by incubation with calcium, accompanied by the morphological changes like epithelial cells in normal keratinocytes. These changes induced by calcium were abolished in the SCC cell lines in which SCCA expression was suppressed by transfection with the antisense cDNA of SCCA. These results suggest that SCCA contributes to the maintenance of the structure of squamous epithelium. The present study will be useful for the establishment of the novel treatment to promote skin maturation in preterm labor infants.

本研究旨在探讨鳞状细胞癌的肿瘤标志物--鳞状细胞癌抗原(SCCA)是否具有刺激细胞间黏附分子的产生和维持鳞状上皮结构的能力。细胞间黏附分子E-钙粘附素的表达随着钙离子浓度的增加而增加，并伴随着正常角质形成细胞中类似上皮细胞的形态变化。在SCCA反义表达被抑制的SCC细胞系中，钙诱导的这些变化被取消。这些结果表明，SCCA有助于维持鳞状上皮的结构。本研究将有助于建立促进早产儿皮肤成熟的新疗法。

项目成果

Suppression of carbonyl reductase 1 promotes tumorigenesis and tumor-associated macrophage migration by induction of epithelial mesenchymal transition

抑制羰基还原酶 1 通过诱导上皮间质转化促进肿瘤发生和肿瘤相关巨噬细胞迁移

• 发表时间: 2012
• 作者: Fujimoto T;Andoh T;Sudo T;Fujita I;Moritake H;Sugimoto T;Sakuma T;Akisue T;Kawabata S;Kirihata M;Suzuki M;Sakurai Y;Ono K;Fukumori Y;Kurosaka M;Ichikawa H;Akihiro MURAKAMI
• 通讯作者: Akihiro MURAKAMI

Relationship between the human leukocyte antigen (HLA) class I expression and the pathogenesis of endometrial cancer

人类白细胞抗原（HLA）I类表达与子宫内膜癌发病的关系

• 发表时间: 2012
• 作者: K. Yakabe;A.Murakami;K. Yoshidomi;K. Sueoka;S. Nawata;N. Sugino
• 通讯作者: N. Sugino

子宮体癌においてcarbonyl reductaseの発現低下が予後不良となる機序の解明

阐明羰基还原酶表达降低导致子宫内膜癌预后不良的机制

• 发表时间: 2012
• 作者: Katagiri A;Nakayama K;Rahman MT;Rahman M;Katagiri H;Ishikawa M;Ishibashi T;Iida K;Otsuki Y;Nakayama S;Miyazaki K;村上 明弘
• 通讯作者: 村上 明弘

Decreased carbonyl reductase 1 expression promotes malignant behaviours by induction of epithelial mesenchymal transition and its clinical significance

• DOI: 10.1016/j.canlet.2012.03.035
• 发表时间: 2012-10-01
• 期刊: CANCER LETTERS
• 影响因子: 9.7
• 作者: Murakami, Akihiro;Yakabe, Kazuyuki;Sugino, Norihiro
• 通讯作者: Sugino, Norihiro

Knockdown of heat shock protein 70 expression suppresses cell migration, invasion and proliferation activities in uterine cervical cancer cells

敲低热休克蛋白70表达抑制宫颈癌细胞的细胞迁移、侵袭和增殖活性

• 发表时间: 2012
• 作者: K. Sueoka;A.Murakami;K. Yakabe;N. Sugino
• 通讯作者: N. Sugino