Targeting tumor metastasis by normalization of tumor blood vessels

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We have isolated two different type of TECs (HM-TEC; isolated from highly metastatic tumor, and LM-TEC; isolated from low metastatic tumor) and found they are different in many aspects. Tumor cells were more attracted and adhesive to HM-TEC in vitro assay. They migrated through the HM-TEC monolayer most among all ECs. To address the question whether TECs contribute to tumor metastasis, low metastatic tumor cells were co-xenografted with each different type of EC (HM-TEC /LM-TEC/NEC) into nude mice. These results suggested that TECs in tumor microenvironment may activelyinduce tumor metastasis.