Development of the radioresistance conquest reinforcement therapy by an EGFR/FGFR dual inhibitor.

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Conventional therapies including radiation therapy cannot cure squamous cell carcinoma and new treatments are clearly required. We identified the radiation resistance related gene (EGFR and FGFR) in the oral cancer cell line to overcome radiotherapy resistance for squamous cell carcinoma. In vivo, irradiation with dual inhibitor (PD173074) of EGFR and FGFR showed effective tumor suppression. Therefore it is considered to be very meaningful for the development of the radiation-enhancing treatment.