Cancer-targeted liposome coupled to viral proteins for imaging cancer cells

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We developed a novel cancer-targeted liposome coupled to sindbis virus proteins (SIN liposome) on the surface that can be used for imaging tumors and an intra-operative navigation system. The imaging efficacy of this liposome was assessed in a nude mouse bearing a tumor using a clinical CT. CT imaging showed that CT signal increases were detected in tumor site treated with SIN liposomes. Thus, this finding that SIN liposomes selectively fused with a tumor suggested the application of this cancer-targeted liposome to cancer imaging.