Development of cancer-targeted liposome with viral proteins

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Targeted liposomes can be broadly defined as liposomes that are engineered to interact with a particular population of cells with the objective of delivering a payload or increasing their retention within the targeted cell population. We previously identifided a Sindbis virus (SIN) strain which preferentially infects several cancers in vitro and in vivo without side effects. In this study, we have developed a cisplatin-encapsulating cancer-targeted liposome with the SIN protein and evaluated its cytotoxicity to cancers in vitro and in vivo. In vitro, the cisplatin-encapsulating cancer-targeted liposome has exhibited higher cytotoxicity to cancer cells than the cisplatin-encapsulating non-targeted liposome. Mice injected with the cisplatin-encapsulating cancer-targeted liposome displayed rapid tumor regression. Thus, this finding that a cisplatin-encapsulating cancer-targeted liposome with the SIN protein selectively fused with cancer cells and sensitized cancer cells suggested the application of this cancer-targeted lipsome to cancer therapy.