The regenerative therapy of the jaw by auto-transplantation of adipose-derived stem cells

通过自体脂肪干细胞移植进行颌骨再生治疗

• 批准号: 23659956
• 负责人: SHINTANI Satoru
• 金额: $ 2.25万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659956/
• 关键词: 脂肪幹細胞; 骨芽細胞; 軟骨細胞; 低侵襲性医療; 骨再生; 骨; 軟骨; 自家移植

In the present study, we revealed as followed.1) The advantages of chemical and mechanicalstress and a cobimation of those on human adipose-derived stem cells (ADSCs) have been revealed. 2) By the transplanation of the diffentiated ADSCs to nude mice, the histochmical and mmolecular-biological investigations of the transplants, wich was succesfully differntiated into bone tissue, have been carried out. 3) It has been suggested that the therapy might contribute the nobel and advantageous regenerative medicine for bone defect of the jaws, since the study was not utilize gene transfection like iPS cells.

在本研究中，我们揭示了以下几点。1)揭示了化学和机械应力及其联合作用于人脂肪干细胞（ADSCs）的优势。2)将分化的ADSCs移植到裸鼠体内，对成功分化为骨组织的移植物进行组织化学和分子生物学研究。3)由于本研究未采用诱导性多能干细胞等基因转染技术，因此有可能为颌骨骨缺损的再生医学治疗做出贡献。

项目成果

Differential expression of vascular endothelial growth factor in high- and low- metastasis cell lines of salivary gland adenoid cystic carcinoma.

血管内皮生长因子在唾液腺腺样囊性癌高转移和低转移细胞系中的差异表达。

• 发表时间: 2014
• 期刊: Anticancer Res., 2014, in press.
• 作者: Kondo;S.;Mukudai;Y.;Soga;D.;Nishida;T.;Takigawa;M. and Shirota;T.
• 通讯作者: T.

Mandibular reconstruction using an autoclave autogenous bone and Iliac particulate cancellous bone and marrow (PCBM).

使用高压灭菌自体骨和髂颗粒松质骨和骨髓 (PCBM) 进行下颌重建。

• 发表时间: 2012
• 作者: Satoru Shintani;Tomohiko Kutsuna;Sayaka Yoshiba;Yuuji Kurihara;Yasumasa Yoshizawa;Yasuto Yoshihama;Seiji Kondo;Tatsuo Shirota
• 通讯作者: Tatsuo Shirota

Potential anti-osteoporotic effects of herbal extracts on osteoclasts, osteoblasts and chondrocytes in vitro.

• DOI: 10.1186/1472-6882-14-29
• 发表时间: 2014-01-17
• 期刊: BMC complementary and alternative medicine
• 作者: Mukudai Y;Kondo S;Koyama T;Li C;Banka S;Kogure A;Yazawa K;Shintani S
• 通讯作者: Shintani S

The root bark extracts of Juncus effusuc and Paeonia suffruticosa protect salivary gland acinar cells from apoptotic cell death induced by cis-platinum (II) diammine dichloride

灯心草和牡丹皮的根皮提取物可保护唾液腺腺泡细胞免受顺铂 (II) 二氯化二胺诱导的细胞凋亡

• 发表时间: 2013
• 期刊: Oncol Rep
• 影响因子: 4.2
• 作者: Koyama;T.;Li;C.;Yazawa;K.;Shintani;S
• 通讯作者: S

A combination of chemical and mechanical stimuli synergistically enhances osteo-and chondro-differentation on adipose-derived stem cells

化学和机械刺激的组合协同增强脂肪干细胞的骨和软骨分化

• 发表时间: 2012
• 作者: Shintani S;Banka S;Mukudai Y;Kondo S
• 通讯作者: Kondo S