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Telomerase-Specific Replication-Selective Virotherapy for oral squamous cell carcinoma cell lines

Telomerase-Specific Replication-Selective Virotherapy for oral squamous cell carcinoma cell lines
针对口腔鳞状细胞癌细胞系的端粒酶特异性复制选择性病毒疗法
批准号:
20390520
负责人:
SHINTANI Satoru
金额:
$12.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
翻译
端粒酶的活化被认为是肿瘤发生的关键步骤,其活性与人端粒酶逆转录酶(human telomerase reverse transcriptase,hTERT)表达密切相关。我们研究了hTERT特异性增殖型腺病毒对口腔鳞状细胞癌(OSCC)细胞的抗肿瘤作用。我们研究了hTERT特异性复制型腺病毒对口腔鳞状细胞癌(OSCC)细胞的抗肿瘤作用。
英文摘要
Telomerase activation is considered to be a critical step in carcinogenesis, and its activity is closely correlated with human telomerase reverse transcriptase (hTERT) expression. We investigated the antitumor effect of the hTERT-specific replication-competent adenovirus on oral squamous cell carcinoma (OSCC) cells. We investigated the antitumor effect of the hTERT-specific replication-competent adenovirus on oral squamous cell carcinoma (OSCC) cells.
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通讯作者:
The regenerative therapy of the jaw by auto-transplantation of adipose-derived stem cells
  • 批准号:
    23659956
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.25万
  • 财政年份:
    2011
  • 负责人:
    SHINTANI Satoru
  • 依托单位:
Basic research for Molecular target therapy on Oral Cancer
  • 批准号:
    14370675
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $9.15万
  • 财政年份:
    2002
  • 负责人:
    SHINTANI Satoru
  • 依托单位:
Cyclin-Dependent Kinase Inhibitor suppresses the growth in oral squamous cell carcinoma cells
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