Telomerase-Specific Replication-Selective Virotherapy for oral squamous cell carcinoma cell lines
Telomerase-Specific Replication-Selective Virotherapy for oral squamous cell carcinoma cell lines
批准号:
20390520
负责人:
SHINTANI Satoru
金额:
$12.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
端粒酶的活化被认为是肿瘤发生的关键步骤,其活性与人端粒酶逆转录酶(human telomerase reverse transcriptase,hTERT)表达密切相关。我们研究了hTERT特异性增殖型腺病毒对口腔鳞状细胞癌(OSCC)细胞的抗肿瘤作用。我们研究了hTERT特异性复制型腺病毒对口腔鳞状细胞癌(OSCC)细胞的抗肿瘤作用。
英文摘要
Telomerase activation is considered to be a critical step in carcinogenesis, and its activity is closely correlated with human telomerase reverse transcriptase (hTERT) expression. We investigated the antitumor effect of the hTERT-specific replication-competent adenovirus on oral squamous cell carcinoma (OSCC) cells. We investigated the antitumor effect of the hTERT-specific replication-competent adenovirus on oral squamous cell carcinoma (OSCC) cells.
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作者:
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通讯作者:
The regenerative therapy of the jaw by auto-transplantation of adipose-derived stem cells
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批准号:23659956
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.25万
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财政年份:2011
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负责人:SHINTANI Satoru
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依托单位:
Basic research for Molecular target therapy on Oral Cancer
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批准号:14370675
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.15万
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财政年份:2002
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负责人:SHINTANI Satoru
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依托单位:
Cyclin-Dependent Kinase Inhibitor suppresses the growth in oral squamous cell carcinoma cells
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批准号:12671938
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2000
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负责人:SHINTANI Satoru
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依托单位:
海外基金