Biochemical marker for prediction of exercise training-induced improvement of arterial stiffness

本研究旨在阐明有规律的有氧运动对中老年人肺鞘蛋白浓度的影响。34名健康的中老年受试者被随机分为两组：运动干预组和久坐对照组。训练组完成为期8周的有氧运动训练（60-70%峰值摄氧量[vo2峰值]，每次45分钟，每周3天）。在训练组中，干预后VO2peak显著升高，颈动脉β僵硬度显著降低。此外，干预后训练组血浆apelin和NOx水平显著升高。此外，血浆apelin水平与颈动脉β -僵硬度之间存在相关性（r = -0.508, P = 0.032）。这些结果表明，血浆内皮蛋白水平的升高可能与运动训练引起的中老年人动脉僵硬度的变化有关。

This study aimed to clarify the effects of regular aerobic exercise on apelin concentrations in middle-aged and older adults. Thirty-four healthy middle-aged and older subjects were randomly divided into two groups: exercise intervention and sedentary controls. Subjects in the training group completed 8-week of aerobic exercise training (60-70% peak oxygen uptake [VO2peak] for 45 min, 3 days/week). In the training group, VO2peak was significantly increased, and carotid beta-stiffness was significantly decreased, after the intervention. Moreover, plasma apelin and NOx levels were significantly increased in the training group after the intervention. Additionally, there was a correlation between the training effects of plasma apelin levels and carotid beta-stiffness (r = -0.508, P = 0.032). These results suggest that the increased in plasma apelin levels may be associated with exercise training-induced alternation of arterial stiffness in middle-aged and older adults.