Biochemical marker for prediction of exercise training-induced improvement of arterial stiffness

用于预测运动训练引起的动脉僵硬度改善的生化标记

• 批准号: 23680071
• 负责人: MOTOYUKI Iemitsu
• 金额: $ 11.56万
• 依托单位: Ritsumeikan University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23680071/
• 关键词: 動脈硬化; 有酸素性運動; バイオマーカー

This study aimed to clarify the effects of regular aerobic exercise on apelin concentrations in middle-aged and older adults. Thirty-four healthy middle-aged and older subjects were randomly divided into two groups: exercise intervention and sedentary controls. Subjects in the training group completed 8-week of aerobic exercise training (60-70% peak oxygen uptake [VO2peak] for 45 min, 3 days/week). In the training group, VO2peak was significantly increased, and carotid beta-stiffness was significantly decreased, after the intervention. Moreover, plasma apelin and NOx levels were significantly increased in the training group after the intervention. Additionally, there was a correlation between the training effects of plasma apelin levels and carotid beta-stiffness (r = -0.508, P = 0.032). These results suggest that the increased in plasma apelin levels may be associated with exercise training-induced alternation of arterial stiffness in middle-aged and older adults.

本研究旨在阐明有规律的有氧运动对中老年人apelin浓度的影响。将34名健康中老年受试者随机分为运动干预组和久坐对照组。训练组完成为期8周的有氧运动训练(60%~70%峰值摄氧量45min，3天/周)。训练组干预后VO2峰值显著升高，颈动脉β-刚性显著降低。此外，训练组干预后血浆apelin和NOx水平显著升高。此外，血浆apelin水平的训练效果与颈动脉β硬度呈正相关(r=-0.508，P=0.032)。这些结果表明，血浆apelin水平的升高可能与运动训练引起的中老年人动脉僵硬的改变有关。

项目成果

Age Differences in the relation between ACTN3 R577X polymorphism and thigh-muscle cross-sectional area in women

女性ACTN3 R577X多态性与大腿肌肉横截面积关系的年龄差异

• 发表时间: 2011
• 期刊: Genet Test Mol Biomarkers
• 作者: Zempo H;Tanabe K;Murakami H;Iemitsu M
• 通讯作者: Iemitsu M

Chlorella intake attenuates reduced salivary SIgA secretion in kendo training camp participants.

• DOI: 10.1186/1475-2891-11-103
• 发表时间: 2012-12-11
• 期刊: Nutrition journal
• 影响因子: 5.4
• 作者: Otsuki T;Shimizu K;Iemitsu M;Kono I
• 通讯作者: Kono I

Higher cardiorespiratory fitness attenuates the risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism

较高的心肺健康可降低与 ADRB3 Trp64Arg 多态性相关的动脉粥样硬化风险

• DOI: 10.1007/s00421-014-2862-5
• 发表时间: 2014
• 期刊: European Journal Applied Physiology
• 作者: Iemitsu M;Fujie S;Murakami H;Sanada K;Kawano H;Gando Y;Kawakami R;Tanaka N;Miyachi M.
• 通讯作者: Miyachi M.

運動効果と遺伝について

关于运动效果和遗传学

• 发表时间: 2012
• 期刊: 成人病と生活習慣病
• 作者: Fuku N;Murakami H;Iemitsu M;Sanada K;Tanaka M;Miyachi M;丹生隆寛,三浦元喜;家光素行;坂東宏和,加藤直樹,三浦元喜;家光素行
• 通讯作者: 家光素行

運動時の神経性循環調節に対する持久トレーニング効果

耐力训练对运动过程中神经循环调节的影响

• 发表时间: 2012
• 作者: Saito Y;Saito H;Liang G;Friedman JM;齊藤満,片山敬章,岩本えりか,石田浩司,金尾洋治,家光素行
• 通讯作者: 齊藤満,片山敬章,岩本えりか,石田浩司,金尾洋治,家光素行