Development of odor sensor based on antigen-responsive hydrogel and its applications

为了实现基于抗原响应水凝胶的气味传感器，研制了亲水性聚合物修饰的传感器表面，用于表面等离子体共振（SPR）传感器。利用传感器表面测量了三硝基甲苯、RDX、催泪剂成分、辣椒素等爆炸物的含量。间接竞争法在表面引发原子转移自由基聚合形成的聚合物表面检测TNT的检出限为5.7 ppt （pg/mL）。位移法测定TNT的LOD为0.4 ppb （ng/mL）。采用间接竞争法对含有低聚乙二醇的自组装单层修饰的传感器表面检测RDX和辣椒素的LOD分别为40 ppt和150 ppb。

To realize odor sensor based on antigen-responsive hydrogel, sensor surfaces modified with hydrophilic polymer were developed for surface plasmon resonance (SPR) sensor. Explosives such as trinitrotoluene, RDX, component of lachrymator, capsaicinoids, were measured using the sensor surfaces. The limit of detection (LOD) for TNT was 5.7 ppt (pg/mL) by indirect competitive method on the polymer surface formed with surface initiated-atom transfer radical polymerization. LOD of 0.4 ppb (ng/mL) for TNT was achieved by displacement method. LOD for RDX and capsaicinoids were 40 ppt and 150 ppb, respectively, using the sensor surfaces modified with self-assembled monolayer containing oligo(ethyleneglycol) by indirect competitive method.