Identification of Novel Intracellular Signal Transduction Pathways Activated by AdipoR1 in the skeletal muscle and the liver

肥胖者血浆脂联素水平降低，从而导致胰岛素抵抗和2型糖尿病。在骨骼肌中，AdipoR1主要表达并激活AMPK和PPARGamma辅活化子(PGC)-1α以及钙信号通路，运动也证明了这些信号通路的激活。因此，我们建议在骨骼肌和肝脏中发现由AdipoR1激活的新的细胞内信号转导通路。此外，我们还在骨骼肌中确定了与运动和AdipoR1信号通路相关的候选关键分子，并阐明了AdipoR1调控肝脏糖异生的机制。

Plasma adiponectin levels are reduced in obesity, which causes insulin resistance and type 2 diabetes. In skeletal muscle, AdipoR1 is predominantly expressed and activates AMPK and PPARgamma coactivator (PGC)-1alpha as well as calcium signalling pathways, which have also been shown to be activated by exercise. So, we proposed to identify the novel intracellular signal transduction pathways activated by AdipoR1 in the skeletal muscle and the liver.We have elucidated the physiological and pathophysiological roles of adiponectin/AdipoR1 in the liver. Moreover, we identified the candidate key molecules relevant to exercise and AdipoR1 signaling pathways in the skeletal muscle, and clarified the gluconeogenesis mechanism regulated by AdipoR1 in the liver.