Clearance of neuronal exosomes in brain平成25年5月20日現在

外泌体是细胞外囊泡的一种亚型，从包括脑神经元在内的各种细胞中释放出来。众所周知，外泌体的功能是清除细胞中过时或错误折叠的蛋白质，然而，外泌体如何在脑细胞外空间加工的机制尚不清楚。在本研究中，我们寻找了可以摄取神经元外泌体的细胞类型，发现小胶质细胞可以摄取外泌体并降解外泌体相关蛋白。

Exosome is a subtype of extracellular vesicle, released from various cells including brain neurons. A well known function of exosome is to remove obsolete or misfolded proteins from cells, however, the mechanism how exosomes are processed in extracellular space of brain remained unclear. In this study, we searched type of cells, which can uptake neuronal exosomes, and found that microglia can uptake the exosomes and degrade the exosome-associated proteins.