Muscle tissue construction by label-free cell assembly based on the magneto-Archimedes effect

本研究基于磁阿基米德效应，设计并制作了一种用于体外三维组织构建的细胞组装装置。为了利用磁阿基米德效应，在培养液中加入顺磁性化合物如磁共振造影剂是必要的。我们证实它的细胞毒性足够低。我们还用研制的装置聚集成肌细胞，并尝试构建3D肌肉组织。

In the present study, a cell assembly device for in-vitro three-dimensional (3D) tissue construction based on the magneto-Archimedes effect was designed and fabricated. So as to utilize the magneto-Archimedes effect, it is necessary to add paramagnetic compound like an MRI contrast agent to the culture medium. We confirmed that its cytotoxicity was low enough. We also aggregated myoblast cells with the developed device and tried construct a 3D muscle tissue.