Comprehensive approach for the prevention of physical frailty focusing on body composition phenotypes of sarcopenia and obesity in older adults

预防身体虚弱的综合方法，重点关注老年人肌肉减少症和肥胖的身体成分表型

• 批准号: 23700820
• 负责人: KIM Miji
• 金额: $ 2.5万
• 依托单位: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700820/
• 关键词: 虚弱高齢者; サルコペニア; 肥満

We investigated the association between physiology, physical function, and body composition phenotypes (normal, sarcopenic, obese, and sarcopenic obesity [SO]) in frail elderly individuals. The hand grip strength and knee extension strength were significantly lower in the SO group than in the normal group. The SO group had significantly higher p2-microglobulin levels than the normal group, but not higher than the sarcopenic and obese groups. Moreover, the SO group spent significantly more time in sedentary behavior and less time in light physical activity than the normal group. In this study, SO was found to be more closely associated with decline in physical function and decrease in physical activity than sarcopenia or obesity alone in frail elderly individuals.

我们研究了体弱老年人的生理、身体功能和身体成分表型（正常、肌肉减少、肥胖和肌肉减少性肥胖[SO]）之间的关系。SO组手部握力和膝关节伸展力明显低于正常组。SO组p2微球蛋白水平明显高于正常组，但不高于肌肉减少组和肥胖组。此外，与正常组相比，SO组花在久坐行为上的时间明显更多，进行轻度体育活动的时间明显更少。在这项研究中，我们发现，在虚弱的老年人中，与肌肉减少症或肥胖相比，SO与身体功能下降和体力活动减少的关系更为密切。

项目成果

Exploring effective items of physical function in slow walking speed and self-reported mobility limitation in community-dwelling older adults

• DOI: 10.1111/j.1447-0594.2011.00726.x
• 发表时间: 2012-01-01
• 期刊: GERIATRICS & GERONTOLOGY INTERNATIONAL
• 影响因子: 3.3
• 作者: Kim, Mi-Ji;Yabushita, Noriko;Tanaka, Kiyoji
• 通讯作者: Tanaka, Kiyoji

地域在住高齢者における多周波部位別生体電気インピーダンス法による身体組成評価の妥当性の検討

检验多频位点生物电阻抗法评估社区老年人身体成分的有效性

• 发表时间: 2012
• 作者: 金美芝;村山洋史;吉田裕人;西真理子;藤原佳典;新開省二;森聖二郎
• 通讯作者: 森聖二郎

Accuracy of segmental multi-frequency bioelectrical impedance analysis for assessing whole-body and appendicular fat mass and lean soft tissue mass in frail women aged 75 years and older

• DOI: 10.1038/ejcn.2013.9
• 发表时间: 2013-04-01
• 期刊: EUROPEAN JOURNAL OF CLINICAL NUTRITION
• 影响因子: 4.7
• 作者: Kim, M.;Kim, H.
• 通讯作者: Kim, H.

Exploring Physical Activity Patterns on Body Composition Phenotypes of Sarcopenia and Obesity in Older Adults.

探索体力活动模式对老年人肌肉减少症和肥胖症身体成分表型的影响。

• 发表时间: 2012
• 作者: Kim MJ;Kim H;Kojima N.
• 通讯作者: Kojima N.

地域在住虚弱高齢者における身体組成と身体機能との関係

社区体弱老年人身体成分与身体机能的关系

• 发表时间: 2011
• 作者: 金美芝;西真理子;村山洋史;吉田裕人;小川貴志子;藤原佳典;深谷太郎;新開省二
• 通讯作者: 新開省二