Preventive effects of polyphenols on TG-rich lipoprotein-induced vascular inflammation

众所周知，血管炎症是动脉粥样硬化的关键一步，在吃了肥胖餐后也会发生。这项研究的目的是调查富含甘油三酯的脂蛋白的促炎作用是否可以通过补充多酚来调节。葡萄多酚可抑制富含甘油三酯的脂蛋白诱导的人脐静脉内皮细胞和THP-1单核细胞的炎症反应。此外，补充葡萄多酚可抑制健康受试者脂肪餐后的血脂升高和炎症反应。

Vascular inflammation is well known to be an crucial step in atherosclerosis and also occurs following a fatty meal. The aims of this study was to investigate whether pro-inflammatory aspects of TG-rich lipoprotein could be modulated by polyphenol supplementation. Grape vine polyphenol inhibited the TG-rich lipoprotein-induced inflammation in the human umbilical vein endothelial cells (HUVEC) and THP-1 monocytic cells. Moreover, the supplementation of grape vine polyphenol suppressed the serum lipid increases and inflammatory responses after fatty meal in healthy subjects.