Mechanisms of oncogenic stress evolution caused by obesity

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Using a bioluminescence imaging system for p16^<INK4a> expression in living mice, we show that oncogenic insults such as obesity and p53 inactivation provoke de-repression of p16INK4a expression in progenitors of adipose tissue. p53 inactivation increases DNA damage and reactive oxygen species(ROS) in progenitors of adipose tissues, indicating that obesity generates oncogenic stress in these cells.